Zarrin Minuchehr

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BACKGROUND The ability of tumour suppressor protein p53 (P53) to regulate cell cycle processes can be modulated by hepatitis B virus (HBV). While preliminary evidences indicates the involvement of protein-x of HBV (HBx) in altering p53 DNA binding, no further data have been accumulated for the significance of serum p53 in chronic hepatitis B virus infected(More)
Amino acids seem to have specific preferences for various locations in alpha-helices. These specific preferences, called singlet local propensity (SLP), have been determined by calculating the preference of occurrence of each amino acid in different positions of the alpha-helix. We have studied the occurrence of amino acids, single or pairs, in different(More)
BACKGROUND There is a novel hypothesis in that antibodies may have specificity for two distinct antigens that have been named "dual specificity". This hypothesis was evaluated for some defined therapeutic monoclonal antibodies (mAbs) such as Trastuzumab, Pertuzumab, Bevacizumab, and Cetuximab. In silico design and construction of expression vectors for(More)
BACKGROUND Trastuzumab (Herceptin) is a humanized monoclonal antibody (mAb) which is used for specific treatment of metastatic breast cancer in patients with overexpression of HER2/neu receptor. In this study, we have attempted to develop a biosimilar version of trastuzumab mAb. METHODS According to in silico studies, the heavy and light chains of(More)
BACKGROUND Even though many functions of protein-x from the Hepatitis B virus (HBV) have been revealed, the nature of protein-x is yet unknown. This protein is well-known for its transactivation activity through interaction with several cellular transcription factors, it is also known as an oncogene. In this work, we have presented computational approaches(More)
BACKGROUND T-cells play an important role in the immune response and are activated in response to the presentation of antigens bound to major histocompatibility complex (MHC) molecules participating with the T-cell receptor (TCR). T-cell receptor complexes also contain four CD3 (cluster of differentiation 3) subunits. The TCR-CD3 complex is vital for T-cell(More)
Chameleon proteins are proteins which include sequences that can adopt α-helix–β-strand (HE-chameleon) or α-helix–coil (HC-chameleon) or β-strand–coil (CE-chameleon) structures to operate their crucial biological functions. In this study, using a network-based approach, we examined the chameleon proteins to give a better knowledge on these proteins. We(More)
During recent years, there has been exponential growth in biological information. With the emergence of large datasets in biology, life scientists are encountering bottlenecks in handling the biological data. This study presents an integrated geographic information system (GIS)-ontology application for handling microbial genome data. The application uses a(More)
Abstr act Backgr ound and pur pose: The expression of more than one third of human genes is appeared to be modulated by MicroRNAs (miRNAs). They control the expression of genes involved in development, growth, proliferation and apoptosis which are vital for cells and tissues. Knowing miRNA systems and their role in the biology of cancers, we could hopefully(More)
The prevalence of allergic diseases has grown in many industrialized and urbanized countries during the last 50 years and outbreak of allergy is increasing in a daily manner. 30 to 40 percent of the populations suffer from allergic diseases. Based on the Increases of different allergies, allergy status has become more difficult in the world. According to(More)
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