Zarina Gioeva

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Apolipoprotein AI-derived (AApoAI) amyloidosis may present either as a non-hereditary form with wild-type protein deposits in atherosclerotic plaques or as a hereditary form due to germline mutations in the APOA1 gene. Currently, more than 50 apoAI variants are known, and 13 are associated with amyloidosis. We describe six patients with AApoAI amyloidosis(More)
AIMS Protein extracts from formalin-fixed and paraffin-embedded (FFPE) tissue for proteomic analysis has recently gained attention. In this study, we explored the possibility to standardize tissue sampling from paraffin blocks and compared the protein extracts with those obtained from fresh frozen material. MATERIALS AND METHODS Fresh frozen and FFPE(More)
The carpal tunnel ligament often encloses transthyretin-derived (ATTR) amyloid deposits. In this study we tested the hypothesis that ATTR amyloid in the carpal tunnel ligament is most commonly of wildtype origin in a Caucasian population without endemic background of familial amyloid polyneuropathy. All resection specimens from the carpal tunnel ligament(More)
AIMS We analysed the suitability of two little known substances for the detection of amyloid in surgical pathology specimens, that is the conjugated polyelectrolyte polythiophene acetic acid (PTAA) and the camelid antibody domain B10. METHODS We compared the amyloid detection of PTAA and B10 to Congo red in 106 amyloid-containing tissue biopsies of(More)
In unserer Studie reevaluierten wir die Histopathologie und Herkunft von Amyloid in Leberbiopsien. Alle Leberbiopsien stammten aus einer Serie von 588 Fällen mit histologisch gesicherter Amyloidose, die zwischen 02/2006 und 01/2009 an das Amyloidregister der Charité eingesendet worden waren. Die Leberbiopsien waren formalinfixiert und in Paraffin(More)
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