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A novel series of 2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazole and 2-substituted thiocarbamoyl-3,3a,4,5,6,7-hexahydro-2H-indazoles derivatives were synthesized and investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). The target molecules were identified on the basis of satisfactory analytical and… (More)
Several 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. In addition, ulcerogenic… (More)
In the structure of the title compound, [Cd(2)(C(4)H(4)NO(4)S)(2)(C(6)H(7)N)(2)], the dinuclear Cd(II) complex is located on a twofold axis with two Cd(2+) ions bridged by two oxide O atoms. Each Cd(2+) ion is additionally coordinated in an equatorial plane by two N and three O atoms of the acesulfamate ligands and axially by two N atoms of the… (More)
The title compound, C(17)H(19)NO(3), adopts the phenol-imine tautomeric form, with a resonance-assisted O-H⋯N intra-molecular hydrogen bond [O⋯N = 2.551 (3) Å]. The dihedral angle between the two benzene rings is 45.42 (7)°. The two meth-oxy groups are coplanar with the attached benzene ring [C-O-C-C torsion angles = -1.1 (5) and 3.2 (4)°].
The title compound, C(14)H(11)Cl(2)NO, is a Schiff base which adopts the phenol-imine tautomeric form in the solid state. There are two mol-ecules in the asymmetric unit. Head-to-tail π-π inter-actions [centroid-to-centroid distances of 3.682 (2), 3.708 (2), 3.904 (2) and 3.910 (2) Å] between adjacent mol-ecules produce two symmetry-independent infinite… (More)
In the crystal structure of the title compound, C(26)H(27)NO(3), a one-dimensional network of C-H⋯O hydrogen bonds and π-ring inter-actions is responsible for crystal stabilization. Inter-molecular hydrogen bonds and C-H⋯ π inter-actions produce R(2) (2)(10), R(4) (4)(27) and R(4) (4)(29) rings.
The title compound, C(13)H(9)Cl(2)NO(2)·H(2)O, represents a Schiff base which adopts the phenol-imine tautomeric form in the solid state. The mol-ecule is approximately planar (r.m.s. deviation 0.0818 Å), and the dihedral angle between the two aromatic rings is 7.46 (12)°. An O-H⋯N inter-action generates an S(6) ring. In the crystal, mol-ecules are linked… (More)
The title compound, C(16)H(17)NO(3), a Schiff base, is stabilized in the solid state in the phenol-imine tautomeric form, with the H atom located on the hydr-oxy O atom rather than on the N atom. This H atom is involved in a strong intra-molecular O-H⋯N hydrogen bond. The mol-ecule is almost planar, the angle between the benzene rings being 4.43 (13)°.… (More)
The title compound, C(18)H(21)NO(3), crystallizes in the phenol-imine tautomeric form, with the H atom attached to oxygen rather than on nitro-gen. This H atom is involved in a strong intra-molecular O-H⋯N hydrogen bond. A C-H⋯π inter-action is also present. The dihedral angle between the aromatic rings is 12.23 (7)°.
In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2- naphthyl)-2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES)… (More)