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We have identified and characterized two different sodium-coupled monocarboxylate cotransporters (SMCT) from zebrafish (Danio rerio), electrogenic (zSMCTe) and electroneutral (zSMCTn). zSMCTn is the 12th member of the zebrafish Slc5 gene family (zSlc5a12). Both zSMCT sequences have approximately 50% homology to human SLC5A8 (hSMCT). Transport function and… (More)
The Chemical Entities of Biological Interest (ChEBI) ontol-ogy is an ontology of chemical entities and their roles, being developed at the European Bioinformatics Institute (EBI). Recent developments include a submission tool for direct user submissions and enhancements to the search facilities available by web services.
Chemical compounds participate in all the processes of life. Understanding the complex interactions of small molecules such as metabolites and drugs and the biological macromolecules that consume and produce them is key to gaining a wider understanding in a systemic context. Chemical property databases collect information on the biological effects and… (More)