Zakaria K Abd El-Samii

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In continuation of our study of novel quinolines with anti-inflammatory activity using the Pfitzinger reaction, several new quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them(More)
Convenient Syntheses of derivatives of the pyrazolo[3,4-d]pyrimidines from 1-(4-benzyl-1-phthalazinyl)-3-amino-4-cyano-5-methylpyrazole (1) and carbon disulphide, aryl isothiocyanates, nitriles or guanidine are described. Derivatives of compound 1 undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen(More)
A series of quinazolinone thiazolidinone and imidazolidinone derivatives were prepared. These compounds were evaluated for their antiinflammatory activity. The most active compounds (6b, 6c and 6d) were found to be superior to phenylbutazone as they were devoid of any ulcerogenic activity.
Diverse biological activities have been found in compounds having a quinazolinone ring system. A large number of 4(3H)-quinazolinones, in particular those possessing 2-alkyl-3-aryl, 2,3-dialkyl, and 2-alkyl-3-amino substitution, have been evaluated for pharmacological activity. On the other hand, thiazolidone derivatives are reported to have anesthetic,(More)
The reaction of 6,7-diamino-1,4-diethyl-11-quinoxaline-1 H,4H-2,3-dione (1) with aliphatic and aromatic carboxylic acids in the presence and absence of an acid catalyst affords 2-alkyl- and 2-aryl-5,8-diethyl-imidazo[4,5-g]quinoxaline-5 H,8 H-6,7-diones 2a-1. Cyclization of 1 with carbon disulphide in basic medium yields(More)
Some novel 1,3,4-oxadiazoline and 1,3,4-oxadiazole derivatives have been synthesized from 3-hydroxy-5,6-diphenyl-1,2,4-triazine. Illucidation of the structures of the isolated products has been proved in the light of their elemental analysis, spectroscopic data and unambiguous synthesis in certain cases. Some derivatives have shown promising(More)
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