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OBJECTIVE To analyze the clinical features and outcome of patients with noncompaction of ventricular myocardium (NVM). METHODS Clinical manifestations, electrocardiograms and echocardiographies data were analyzed in 18 patients with NVM. Mean follow-up period was (11 +/- 5) months. RESULTS The patients aged from 1.5 to 71 years, 66.7% patients were(More)
Endothelial cells play a vital role in the maintenance of cardiovascular homeostasis. Epoxyeicosatrienoic acids (EETs), cytochrome P-450 (CYP) epoxygenase metabolites of arachidonic acid in endothelial cells, possess potent and diverse biological effects within the vasculature. We evaluated the effects of overexpression of CYP epoxygenases on tumor necrosis(More)
AIM To investigate the effects of chronic treatment with imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks. Myocytes were isolated(More)
Experiments were performed to investigate the heterogeneity of the action potential and ion currents in left ventricular myocytes of the rabbit. Myocytes were isolated by enzymatic method. The sub-endocardial (Endo) and sub-epicardium (Epi) tissues were separated from the other region (midmyocardium, M) with a razor. Single cells in each region were(More)
Shilin Yang,* Li Lin,* Ji-Xiong Chen,* Craig R. Lee, John M. Seubert, Yan Wang, Hong Wang, Zhong-Ren Chao, De-Ding Tao, Jian-Ping Gong, Zai-Ying Lu, Dao Wen Wang, and Darryl C. Zeldin Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic(More)
AIM To investigate the transmural heterogeneous change of slow component of delayed rectifying potassium current in rabbit left ventricular hypertrophic myocytes and the effect of long-term treatment with imidapril (Imi). METHODS Rabbits were divided into hypertrophy group (left ventricular hypertrophy induced by partial ligation of abdominal aorta),(More)
AIM To investigate the effects of imidapril (IMI) on effective refractory period (ERP) and sodium current (I(Na)) of myocytes in ventricular noninfarction zone of healed myocardial infarction (HMI) in rabbit models. METHODS Rabbits with left coronary artery ligation were prepared and IMI (0.625 mg x kg(-1) x d(-1), 8 weeks) was orally administered. The(More)
BACKGROUND SMAD proteins have recently been identified as the first family of putative transforming growth factor-beta1 (TGF-beta1) signal transducers. This study was to investigate the effects of TGF-beta1 and signal protein Smad3 on rat cardiac hypertrophy. METHODS The incorporation of [(3)H]-leucine was measured to determine the hypertrophy of(More)
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