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There is a problem in the spatial and temporal separation between the varying forms of representation used in urban design. Sketches, physical models, and more recently computational simulation, while each serving a useful purpose, tend to be incompatible forms of representation. The contemporary designer is required assimilate these divergent media into a(More)
Previous studies have reported an incidence of amiodarone-induced pulmonary toxicity (AIPT) of 5% to 10% with high doses of amiodarone (greater than 400 mg daily). A lower rate of 1.6% is recorded from combined placebo controlled, double-blind trials involving 3439 patients receiving daily amiodarone doses of 400 mg or less. Although the rate of diagnosis(More)
BACKGROUND Electrolyte imbalances are frequently encountered in the Intensive Care Unit (ICU) and protocol-driven interventions may facilitate more timely and uniform care. OBJECTIVE To compare the effectiveness and timeliness of electrolyte replacement in an adult ICU before and after implementation of an Electrolyte Replacement Protocol (ERP) and to(More)
African Americans have a markedly higher incidence of ESRD compared with other racial groups. Two variants in the APOL1 gene, to date observed only among individuals of recent African ancestry, associate with increased risk for renal disease among African Americans. Here, we investigated whether these risk alleles also associate with age at initiation of(More)
Amiodarone-induced pulmonary toxicity (AIPT) is one of the most serious adverse effects of amiodarone therapy and can be fatal. Therefore, vigilant monitoring is advised. Baseline chest radiograph and pulmonary function tests and follow-up chest films at 3-month intervals are advocated. However, since abnormalities on these two examinations do not always(More)
STUDY OBJECTIVE To determine whether use of a smaller needle size for subcutaneous injection of enoxaparin would reduce the size of injection-site hematomas and/or decrease the pain of injection. DESIGN Prospective, randomized trial. SETTING Community hospital in North Vancouver, British Columbia, Canada. PATIENTS One hundred twenty-four patients with(More)
Nitrofurantoin is an antimicrobial agent that is commonly used to treat urinary tract infections. It may also be used prophylactically for patients with recurrent urinary tract infection. Several cases and various clinical manifestations of pulmonary reactions to nitrofurantoin have been described in the literature. Early recognition of such reactions may(More)
OBJECTIVE To determine the median time to antibiotic administration following the onset of septic shock at our institution as well as the appropriateness of empiric therapy, sources of delay in antibiotic administration and the effect of delays on survival. RESEARCH METHODOLOGY Retrospective health record review of 55 patients with septic shock admitted(More)