Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3.

• Jianying Li, John Wang, Zafar Nawaz, J. M. Liu, J. Qin, Janice Wong
• The EMBO journal
• 2000

We present evidence that both corepressors SMRT and N-CoR exist in large protein complexes with estimated sizes of 1.5-2 MDa in HeLa nuclear extracts. Using a combination of conventional and… (More)

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation.

• David M. Lonard, Zafar Nawaz, C. Lavett Smith, B. O'Malley
• Molecular cell
• 2000

Estrogen receptor-alpha (ER alpha) is downregulated in the presence of its cognate ligand, estradiol (E2), through the ubiquitin proteasome pathway. Here, we show that ubiquitin proteasome function… (More)

Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.

• C. Lavett Smith, Zafar Nawaz, B. O'Malley
• Molecular endocrinology
• 1997

Mixed antiestrogens, such as 4-hydroxytamoxifen (4HT), act as either partial agonists or antagonists of estrogen receptor (ER) function in a tissue-, cell-, and promoter-specific manner, suggesting… (More)

The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.

• Zafar Nawaz, David M. Lonard, +4 authors B. O'Malley
• Molecular and cellular biology
• 1999

In this study, we found that the E6-associated protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a… (More)

Proteasome-dependent degradation of the human estrogen receptor.

• Zafar Nawaz, David M. Lonard, Alexis Dennis, C. Lavett Smith, B. O'Malley
• Proceedings of the National Academy of Sciences…
• 1999

In eukaryotic cells, the ubiquitin-proteasome pathway is the major mechanism for the targeted degradation of proteins with short half-lives. The covalent attachment of ubiquitin to lysine residues of… (More)

Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

• Neil J. McKenna, J. Xu, Zafar Nawaz, S. Y. Tsai, M. J. Tsai, B. O'Malley
• The Journal of steroid biochemistry and molecular…
• 1999

Nuclear receptors are ligand-inducible transcription factors which mediate the physiological effects of steroid, thyroid and retinoid hormones. By regulating the assembly of a transcriptional… (More)

Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor.

• S. M. Ziauddin Hyder, Zafar Nawaz, Constance L Chiappetta, George M. Stancel
• Cancer research
• 2000

Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis and a prognostic factor for many tumors including those of endocrine-responsive tissues such as the breast and uterus.… (More)

Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+…

• Bankim Shah, Zafar Nawaz, +4 authors A. Gilani
• Biochemical pharmacology
• 1999

Curcumin, a dietary spice from turmeric, is known to be anti-inflammatory, anticarcinogenic, and antithrombotic. Here, we studied the mechanism of the antiplatelet action of curcumin. We show that… (More)

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

• Suzanne A W Fuqua, Shane Fitzgerald, +6 authors Will iam L. McGuire
• Cancer research
• 1992

It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But… (More)

15q overgrowth syndrome: a newly recognized phenotype associated with overgrowth, learning difficulties, characteristic facial appearance, renal anomalies and increased dosage of distal chromosome…

• Katrina Tatton-Brown, Daniela T. Pilz, +15 authors Meriel E. McEntagart
• American journal of medical genetics. Part A
• 2009

Trisomy and tetrasomy of distal chromosome 15q have rarely been reported. Although most of the described patients have some learning difficulties and are overgrown, the phenotype associated with… (More)

• ‹
• 1
• 2
• 3
• 4
• 5
• ›