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An expanding world of small RNAs.
In ciliated protozoans, small RNAs (sRNAs) are integral to guiding large-scale genomic rearrangements after mating. Sandoval et al. (2014) report in this issue of Developmental Cell the discovery of… Expand
Mating of the Stichotrichous Ciliate Oxytricha trifallax Induces Production of a Class of 27 nt Small RNAs Derived from the Parental Macronucleus
Ciliated protozoans possess two types of nuclei; a transcriptionally silent micronucleus, which serves as the germ line nucleus, and a transcriptionally active macronucleus, which serves as the… Expand
From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.
- F. Michelini, Ameya P. Jalihal, +13 authors F. d'Adda di Fagagna
- Chemistry, Medicine
- Chemical reviews
- 30 March 2018
Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA,… Expand
RNA-mediated transgenerational inheritance in ciliates and plants
In the age of next-generation sequencing (NGS) and with the availability of whole sequenced genomes and epigenomes, some attention has shifted from purely sequence-based studies to those of heritable… Expand
Preferential expression of scores of functionally and evolutionarily diverse DNA and RNA-binding proteins during Oxytricha trifallax macronuclear development
During its sexual reproduction, the stichotrichous ciliate Oxytricha trifallax orchestrates a remarkable transformation of one of the newly formed germline micronuclear genomes. Hundreds of thousands… Expand
Macronuclear development in the ciliate Oxytricha trifallax
- Zachary T Neeb
Oxytricha trifallax, like all ciliated protozoans, possess two distinct types of nuclei: a germline micronucleus that is transcriptionally silent and a somatic macronucleus used for vegetative growth… Expand