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It is demonstrated that phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol to 150 mmol using phenylacetyl disulfide (PADS) as an efficient and economical replacementContinue Reading
  • Zacharia S. Cheruvallath, Ravinash Krishna Kumar, Claus Rentel, D. L. Cole, Vasulinga T. Ravikumar
  • Chemistry, Medicine
  • Nucleosides, nucleotides & nucleic acids
  • 1 July 2003
  • Diethyldithiodicarbonate (DDD), a cheap and easily prepared compound, is found to be a rapid and efficient sulfurizing reagent in solid phase synthesis of phosphorothioate oligodeoxyribonucleotidesContinue Reading
  • Zacharia S. Cheruvallath, Mingnam Tang, +13 authors Christopher J. Larson
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 June 2016
  • Methionine aminopeptidase 2 (MetAP2) is an enzyme that cleaves an N-terminal methionine residue from a number of newly synthesized proteins. Pre-clinical and clinical studies suggest that MetAP2Continue Reading
    Abstract Two novel taxol analogues, baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-phenylisoserinate) ( 2 ) and baccatin III 13-(N-benzoyl-(2′R,3′S)-3′(p-chlorophenyl)isoserinate) ( 3 ) wereContinue Reading