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Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
TLDR
The findings demonstrated that the genetic architecture of ALS in Asian populations is distinct from that in European populations, which need to be given appropriate consideration when performing genetic testing of patients with ALS.
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De novo FUS gene mutations are associated with juvenile-onset sporadic amyotrophic lateral sclerosis in China
View on Elsevier
Screening for C9orf72 repeat expansions in Chinese amyotrophic lateral sclerosis patients
View on Elsevier
Toward precision medicine in amyotrophic lateral sclerosis.
TLDR
This review considers applying the key elements of precision medicine to ALS: phenotypic classification, comprehensive risk assessment, presymptomatic period detection, potential molecular pathways, disease model development, biomarker discovery and molecularly tailored interventions.
View on PubMed
Identification of a novel missense mutation in angiogenin in a Chinese amyotrophic lateral sclerosis cohort
TLDR
The findings highlight that the genetic background of ALS differs between different populations, and suggest that ANG mutation may be involved in the aetiology of ALS in the Han Chinese population.
View on Taylor & Francis
Short-term versus long-term hormone therapy plus radiotherapy or prostatectomy for prostate cancer: a systematic review and meta-analysis
TLDR
Long-term HT plus RT showed a trend toward improved overall survival; long-termHT plus RP declined positive surgical margin rate and prostate volume before RP, and the adverse reactions are inevitable.
View on Springer
The distinctive genetic architecture of ALS in mainland China
TLDR
An extensive review of the literature was performed to determine the mutation frequencies of major ALS-related genes in mainland China, and the burden of mutations across SOD1, ANG, TARDBP, FUS and C9orf72 within mainland Chinese was compared to that within Caucasian populations.
View on BMJ
Screening of VCP mutations in Chinese amyotrophic lateral sclerosis patients
View on Elsevier
Mutations in FUS are the most frequent genetic cause in juvenile sporadic ALS patients of Chinese origin
TLDR
The results suggest that FUS mutations are the most frequent genetic cause in early-onset sporadic ALS patients of Chinese origin, and genetic testing of FUS should be performed in early -onset ALS patients especially those with an aggressive disease course.
View on Taylor & Francis
Screening of the TARDBP gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin
View on Elsevier
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