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Cancer prevention with promising natural products: mechanisms of action and molecular targets.
- P. Pratheeshkumar, C. Sreekala, +9 authors X. Shi
- Biology, Medicine
- Anti-cancer agents in medicinal chemistry
- 30 November 2012
Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important… Expand
Salmonella enteritidis ghost vaccine induces effective protection against lethal challenge in specific-pathogen-free chicks.
Bacterial ghosts (BGs) are empty bacterial envelopes generated by expulsion of the bacterial genome and cytoplasmic contents from bacterial cells, and the process is mediated by lysis protein E… Expand
Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release
The mechanisms contributing to an increased risk of thrombosis in uremia are complex and require clarification. There is scant morphological evidence of membrane-dependent binding of factor Xa (FXa)… Expand
Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor.
Understanding of NAD+ metabolism provides many critical insights into health and diseases, yet highly sensitive and specific detection of NAD+ metabolism in live cells and in vivo remains difficult.… Expand
Arsenite induces HIF-1α and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells
Arsenite is widely distributed environmental toxicant in water, food and air. It is a known human carcinogen, which is strongly associated with human cancers originated from liver, nasal cavity,… Expand
Preclinical comparison of the blood brain barrier (BBB) permeability of osimertinib (AZD9291) with other irreversible next generation EGFR TKIs
Hyperactivated peripheral invariant natural killer T cells correlate with the progression of HBV‐relative liver cirrhosis
Invariant NKT (iNKT) cells express markers of both T and NK cells and may produce various cytokines to regulate liver immunity. However, the role of iNKT cells in the progression of HBV‐relative… Expand
Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function
- Q. Xiang, Shun-dong Ji, Z. Zhang, Xia Zhao, Y. Cui
- BioMed research international
- 14 November 2016
The aim of the study was to investigate ITGA2B and ITGB3 genetic polymorphisms and to evaluate the variability in the platelet function in healthy Chinese subjects. The genetic sequence of the entire… Expand
Establishment of BV2 microglia polarization model and its effect on Toxoplasma gondii proliferation.
- Longtao Wang, Q. Liu, +7 authors Xi-jun He
- Biology, Medicine
- Research in veterinary science
- 1 August 2019
Toxoplasma gondii is an intracellular opportunistic, parasitic protozoan. Microglia have been classified into two main types: M1 (classically activated macrophages) and M2 (alternatively activated… Expand
Downregulation of NEDD 9 by apigenin suppresses migration , invasion , and metastasis of colorectal cancer cells
Apigenin is a natural flavonoid which possesses multiple anti-cancer properties such as antiproliferation, anti-inflammation, and anti-metastasis in many types of cancers including colorectal cancer.… Expand