• Publications
  • Influence
Prediction of low-energy collision-induced dissociation spectra of peptides.
  • Z. Zhang
  • Medicine, Chemistry
  • Analytical chemistry
  • 21 May 2004
A kinetic model, based on the "mobile proton" model of peptide fragmentation, was developed to quantitatively simulate the low-energy collision-induced dissociation (CID) spectra of peptidesExpand
  • 226
  • 20
Naturally occurring glycan forms of human immunoglobulins G1 and G2.
High resolution glycan mapping was performed on human immunoglobulin G (IgG) obtained from individual healthy subjects and from a combined sample of healthy subjects. In addition to the commonlyExpand
  • 85
  • 9
Prediction of low-energy collision-induced dissociation spectra of peptides with three or more charges.
  • Z. Zhang
  • Chemistry, Medicine
  • Analytical chemistry
  • 27 August 2005
A kinetic model, based on the "mobile proton" model of peptide fragmentation, has been reported previously for quantitative prediction of low-energy collision-induced dissociation (CID) spectra ofExpand
  • 100
  • 9
G/U and certain wobble position mismatches as possible main causes of amino acid misincorporations.
A mass spectrometry-based method was developed to measure amino acid substitutions directly in proteins down to a level of 0.001%. When applied to recombinant proteins expressed in Escherichia coli,Expand
  • 61
  • 8
High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.
Glycan structures attached to the C(H)2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in modulating clearance is less clear. ClearanceExpand
  • 286
  • 7
Large-scale identification and quantification of covalent modifications in therapeutic proteins.
  • Z. Zhang
  • Medicine, Chemistry
  • Analytical chemistry
  • 18 September 2009
Covalent modifications on therapeutic proteins are traditionally monitored by chromatographic techniques, which quantify limited number of protein modifications at a time. In this report, computerExpand
  • 64
  • 6
An enhanced fall detection system for elderly person monitoring using consumer home networks
Various fall-detection solutions have been previously proposed to create a reliable surveillance system for elderly people with high requirements on accuracy, sensitivity and specificity. In thisExpand
  • 161
  • 6
  • Open Access
Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms*
In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody could be partially resolved intoExpand
  • 216
  • 5
Improved protein hydrogen/deuterium exchange mass spectrometry platform with fully automated data processing.
Protein hydrogen/deuterium exchange (HDX) followed by protease digestion and mass spectrometric (MS) analysis is accepted as a standard method for studying protein conformation and conformationalExpand
  • 78
  • 5
Mass spectrometry for structural characterization of therapeutic antibodies.
Antibodies, also known as immunoglobulins, have emerged as one of the most promising classes of therapeutics in the biopharmaceutical industry. The need for complete characterization of the qualityExpand
  • 227
  • 4