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Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus
Pelgipeptins are highly potent antibacterial and antifungal agents, particularly against MRSA, and warrant further investigation as possible therapeutic agents for bacteria infections resistant to currently available antibiotics.
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa.
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.
Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.
Paenimacrolidin, a novel macrolide antibiotic from Paenibacillus sp. F6‐B70 active against methicillin‐resistant Staphylococcus aureus
To the authors' knowledge, this is the first report of the isolation of an active macrolide from paenibacilli, which may be a promising source of novel antibiotics.
Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis.
Five new sesquiterpene lactones, namely vernchinilides A-E (1-5), along with five known compounds, were isolated from Vernonia chinensis and the structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques.
Lignans from Saussurea conica and their NO production suppressing activity.
Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica, and two of them showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.
Sesquiterpenoid alkaloid from Acroptilon repens
One new sesquiterpenoid alkaloid, namely 3β,8α-dihydroxy-13-pyrrolidine-4(15),10(14)-(1αH,5αH,6βH,11βH)-guaiadien-12,6-olide (1), together with two known guaiane-type sesquiternoids (2−3) was…
Diterpenoids and a Diarylheptanoid from Hedychium coronarium with Significant Anti‐Angiogenic and Cytotoxic Activities
- Z. Zhan, Yan-Tao Wen, Feng-Yun Ren, Gui-Wei Rao, W. Shan, Cheng‐Ping Li
- Chemistry, BiologyChemistry & biodiversity
- 1 December 2012
Two new labdane diterpenoids, namely hedycoronals A and B (1 and 2, resp.), were isolated from the rhizomes of Hedychium coronarium and showed moderate or potent cytotoxic activities against four cancer cell lines.
This review covers the isolation, structural determination, biological activities and biomimetic synthesis of all natural dimeric sesquiterpenoids, along with a detailed discussion of the biogenesis…