Z. Zhai

Publications46
h-index30
Citations5,614
Highly Influential Citations331
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VISA is an adapter protein required for virus-triggered IFN-beta signaling.
TLDR
Depletion of VISA inhibits virus-triggered and RIG-I-mediated activation of IRF-3, NF-kappaB, and the IFN-beta promoter, suggesting that VISA plays a central role in virus- Triggered TLR3-independent IFn-beta signaling.
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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response…
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PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
TLDR
The PCBP2-AIP4 axis defines a new signaling cascade for MAVS degradation and 'fine tuning' of antiviral innate immunity.
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AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis*
TLDR
It is suggested that AMID induces a novel caspase-independent apoptotic pathway, which lacks a mitochondrial localization sequence but shares significant homology with AIF and NADH oxidoreductases from bacteria to mammalian species.
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SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
TLDR
Findings suggest that SIKE is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF-3 but not NF-kappaB activation pathways.
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ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
TLDR
It is suggested that ZNF216 and A20 have redundant and distinct roles in regulating NFkappaB activation and apoptosis.
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Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β
TLDR
It is shown that overexpression of LBR causes membrane overproduction, inducing NE invagination and membrane stack formation, and that these processes require the transmembrane domain of LDR, which is recruited to chromatin through direct interaction with importin β to contribute to the fusion of membrane vesicles and formation of the NE.
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SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways
TLDR
Findings suggest that SIKE is a physiological suppressor of IKKε and TBK1 and plays an inhibitory role in virus‐ and TLR3‐triggered IRF‐3 but not NF‐κB activation pathways.
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GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth
TLDR
GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is required for GIDE's E3 ligase activity, and these pro-apoptotic or growth inhibition effects of GIDE may account for its absence in tumor cells.
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