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Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells
TLDR
Microarray and bioinformatics data analyses revealed that the putative lung CSCs have molecular signatures of both normal and cancer stem cells and that the most prominent biological functions are associated with angiogenesis, migration, pro-APoptosis and anti-apoptosis, osteoblast differentiation, mesenchymal cell differentiation, and mesenchyme development.
Cytogenetic Profile of de novo Acute Myeloid Leukemia Patients in Malaysia
TLDR
The karyotypic patterns of 480 patients with de novo AML seen at government hospitals throughout the country were examined and the association of chromosome aberrations with the age of patient was evaluated to show different cytogenetic abnormalities in AML show different frequencies with increasing age.
Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells.
TLDR
The data suggest that MSC from different sources can be explored for distinct therapeutic roles, and several Glutamic acid-Leucine-Arginine; ELR-positive CXC chemokine genes and secretion of growth factors, which promote angiogenesis, were found to be up-regulated in WJ MSC.
Distribution of HPV genotypes in cervical cancer in multi- ethnic Malaysia.
TLDR
This study showed that the distribution of HPV genotypes in Malaysia is similar to other Asian countries, and found that different ethnic groups in Malaysia have different HPV genotype infection rates, which is a point to consider during the implementation of HPV vaccination.
Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer
TLDR
Findings add credibility to the utilization of MSC-TRAIL for the treatment of NSCLC through targeting of CD133+ CSCs through induction of mitochondria membrane potential and TNF-related apoptosis.
Cell therapy in critical limb ischemia: current developments and future progress.
TLDR
Up-to-date progress and developments in cell-based therapy are described as a novel and promising alternative for CLI treatment, with significant hurdles remain to be addressed.
Growth Inhibition of Human Gynecologic and Colon Cancer Cells by Phyllanthus watsonii through Apoptosis Induction
TLDR
Results demonstrated that P. watsonii selectively inhibits the growth of SKOV-3, Ca Ski and HT-29 cells through apoptosis induction and cell cycle modulation and has the potential to be further exploited for the discovery and development of new anti cancer drugs.
Micromanipulation of culture niche permits long-term expansion of dental pulp stem cells—an economic and commercial angle
TLDR
The adoption of an appropriate culture system significantly improved cell yield, thus enabling the attainment of sufficient yields for therapeutic applications economizing in terms of cost of production and minimizing seeding cell density for maximum yield.
Preliminary Screening of Antibacterial Activity Using Crude Extracts of Hibiscus rosa sinensis.
TLDR
H. rosa sinensis extract is a potential antibacterial agent for treating MRSA infection and is evaluated using a disc diffusion method.
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