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The significance of human jagged 1 mutations detected in severe cases of extrahepatic biliary atresia
Mutations of human jagged 1 (JAG1) gene are responsible for Alagille Syndrome (AGS), whose 2 main symptoms are intrahepatic bile duct hypoplasia and pulmonary stenosis. We examined the JAG1 mutation… Expand
Mutational analysis of the Jagged 1 gene in Alagille syndrome families.
Alagille syndrome (AGS) is an autosomal dominant disease characterized by five major abnormalities in the liver, heart, face, vertebrae and eye. The responsible gene has been recently identified as… Expand
The DSL domain in mutant JAG1 ligand is essential for the severity of the liver defect in Alagille syndrome
Alagille syndrome (AGS) is a congenital multi‐system anomaly mainly characterized by paucity of intrahepatic bile ducts caused by haploinsufficiency of the Jagged 1 gene (JAG1). To explore the… Expand
Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells.
Chloramphenicol is a broad-spectrum antibiotic used for the treatment of many infectious diseases and has become one of the major seafood contaminants. Hematologic disorders such as aplastic anemia… Expand
Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid
- C. D. Krause, L. Izotova, +5 authors S. Pestka
- Biology, Medicine
- Stem Cell Research & Therapy
- 14 March 2011
IntroductionLocal synthesis of interferon within B16 tumors mediates anti-tumor effects. Based on reports that stem cells are recruited to tumors, and because systemic administration of interferon… Expand
Human Jagged 1 mutants cause liver defect in Alagille syndrome by overexpression of hepatocyte growth factor.
Alagille syndrome (AGS, MIM 118450) is an autosomal dominant inherited disease. Paucity of interlobular bile ducts is one of the major abnormalities. To explore the molecular mechanism by which… Expand
[Effect of processing on the alkaloids in Strychnos nux-vomica L].
- H. Wu, B. Cai, P. Zheng, C. Zhao, Z. Yuan
- Chemistry, Medicine
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao…
- 1 May 1994
The contents of strychnine, brucine, isostrychnine and isobrucine in different processed products of Strychnos nux-vomica were determined by TLC-densitometry. The relationship of the contents of… Expand
Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis.
Apoptosis plays a critical role in cellular homeostasis during development, immune responses, and tumorigenesis. Recent studies have identified a number of genes that control this process. We report… Expand
Linkage analysis and identification of deletion in Alagille syndrome gene
- Z. Yuan, T. Kohsaka, N. Kobayashi
- Biology, Medicine
- Acta paediatrica Japonica : Overseas edition
- 1 December 1997
Alagille syndrome (AGS) is a genetic disease and the responsible gene has already been mapped at 20p12. To more accurately detect the region of the AGS gene on the linkage map of chromosome 20p, 14… Expand
Chloramphenicol promotes abnormal cell differentiation and inhibits apoptosis: A potential link to leukemia
Proc Amer Assoc Cancer Res, Volume 45, 2004 1537 Chloramphenicol is a broad-spectrum antibiotic and has been used to effectively control various infectious diseases worldwide. However, the… Expand