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A Meta-Analysis Comparing Postoperative Complications and Outcomes of Femtosecond Laser-Assisted Cataract Surgery versus Conventional Phacoemulsification for Cataract
Compared with CPCS, FLACS might achieve higher refractive stability and corneal endothelial cell count, and further study is needed to validate the findings. Expand
Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis.
It is suggested that HO-1 protects human lens epithelial cells from H2O2-induced oxidant stress by upregulating antioxidant enzyme activity, reducing ROS generation, and thus inhibiting caspase family-dependent apoptosis. Expand
miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway
Background Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). The autophagy-lysosome pathway (ALP) is one of the main intracellularExpand
Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome
Inflammatory cytokines may be involved in the pathogenesis of late-onset capsular block syndrome and surgical treatment is an effective approach, and opaque substance is derived from human lens epithelial cells. Expand
Nrf2 protects human lens epithelial cells against H2O2‐induced oxidative and ER stress: The ATF4 may be involved
  • T. Ma, D. Lan, +13 authors Z. Li
  • Chemistry, Medicine
  • Experimental eye research
  • 1 April 2018
The data suggests a novel interaction between Nrf2 and ATF4 under oxidative and ER stress, thus drives specific enzymatic and non‐enzymatic reactions of antioxidant mechanisms maintaining redox homeostasis. Expand
Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)–induced oxidative stress and the activation of NF‐&kgr;B signaling in lens epithelial cells
It is suggested that low concentrations of CO protect LECs from H2O2‐induced oxidative damage by attenuating NF‐&kgr;B p65 nuclear translocation, reducing the generation of ROS and apoptotic molecules, and restoring antioxidant enzyme levels, thereby inhibiting L ECs apoptosis. Expand
Effect of Aβ protein on inhibiting proliferation and promoting apoptosis of retinal pigment epithelial cells.
Aβ protein inhibits cell proliferation and activates apoptosis via inactivation of the RAGE/NF-κB signaling pathway in RPE cell, confirming that RAGE /NF-β signaling pathway is involved in the regulation of Aβ protein on R PE cell apoptosis and proliferation. Expand
Identification of potential molecular targets associated with proliferative diabetic retinopathy
HIF1A, PGF, KIF11, G protein subunits, and miR-136, miR -374 may all be involved in angiogenesis, retinal endothelial cell proliferation, and visual signal transduction in proliferative DR. Expand
Management of Cataract in Patients with Irregular Astigmatism with Regular Central Component by Phacoemulsification Combined with Toric Intraocular Lens Implantation
Toric IOL implantation has a good corrective effect on certain specific types of corneal irregular astigmatism with cataract, which can be attributed to its ability to correct the regular component of irregularAstigmatism. Expand
Long non‑coding RNA associated‑competing endogenous RNAs are induced by clusterin in retinal pigment epithelial cells.
The present study uncovered and characterized via bioinformatics the global properties of the ceRNA network in human RPE cells in response to clusterin, which may aid in the elucidation of the molecular mechanisms of clusterin in age‑related macular degeneration. Expand