• Publications
  • Influence
A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway*
  • Z. Yao, G. Zhou, +4 authors T. Tan
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 22 January 1999
The yeast serine/threonine kinase STE20 activates a signaling cascade that includes STE11 (mitogen-activated protein kinase kinase kinase), STE7 (mitogen-activated protein kinase kinase), andExpand
  • 150
  • 13
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.
  • K. Diener, X. Wang, +5 authors Z. Yao
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 September 1997
The c-Jun N-terminal kinase (JNK), or stress-activated protein kinase plays a crucial role in cellular responses stimulated by environmental stress and proinflammatory cytokines. However, theExpand
  • 130
  • 11
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.
Secretion of triacylglycerol-enriched very-low-density lipoproteins (VLDLs) from the liver is vital for maintaining plasma lipid homeostasis. However, the process of VLDL assembly and lipidation isExpand
  • 164
  • 9
MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.
A novel protein kinase that has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK) was identified. This novel protein kinase has a nucleotideExpand
  • 101
  • 9
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion
Excess lipid induced metabolic disorders are one of the major existing challenges for the society. Among many different causes of lipid disorders, overproduction and compromised catabolism ofExpand
  • 130
  • 9
Intracellular Assembly of Very Low Density Lipoproteins Containing Apolipoprotein B100 in Rat Hepatoma McA-RH7777 Cells*
Previous studies with McA-RH7777 cells showed a 15–20-min temporal delay in the oleate treatment-induced assembly of very low density lipoproteins (VLDL) after apolipoprotein (apo) B100 translation,Expand
  • 105
  • 7
The Activity of Microsomal Triglyceride Transfer Protein Is Essential for Accumulation of Triglyceride within Microsomes in McA-RH7777 Cells
Previously, based on distinct requirement of microsomal triglyceride transfer protein (MTP) and kinetics of triglyceride (TG) utilization, we concluded that assembly of very low density lipoproteinsExpand
  • 123
  • 6
Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase
Transforming growth factor β (TGF-β)-activated kinase (TAK1) is known for its involvement in TGF-β signaling and its ability to activate the p38-mitogen-activated protein kinase (MAPK) pathway. ThisExpand
  • 185
  • 5
Identification of stathmin as a novel substrate for p38 delta.
p38 mitogen-activated protein kinases (MAPK) are a family of kinases that are activated by cellular stresses and inflammatory cytokines. Although there are many similarities shared by the isoforms ofExpand
  • 80
  • 5
Hematopoietic Progenitor Kinase 1 Is a Component of Transforming Growth Factor β-induced c-Jun N-terminal Kinase Signaling Cascade*
The c-Jun N-terminal kinase (JNK) signaling pathway is involved in transforming growth factor β (TGF-β) signaling in a variety of cell systems. We report here that hematopoietic progenitor kinase 1Expand
  • 76
  • 5