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Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.
By operating as an IGF-II antagonist, theIGF-IIR has tumor suppressor-like properties, a suggestion consistent with reports of loss of heterozygosity at the IGF- IIR locus in a variety of human malignancies. Expand
LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
  • K. Tamura, Y. Chen, +7 authors V. Dzau
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 July 2000
A function for LXRalpha is described as a cAMP-responsive regulator of renin and c-myc gene transcriptions by the interaction with a specific cis-acting DNA element, CNRE (an overlapping cAMP response element and a negative response element). Expand
Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft
The pharmacokinetics of Cetuximab in nude mice at efficacious dose levels was characterized and the preclinical optimal dose and active plasma drug concentration with those determined in clinical studies were compared. Expand
Induction of apoptotic cell death and in vivo growth inhibition of human cancer cells by a saturated branched-chain fatty acid, 13-methyltetradecanoic acid.
The preliminary data demonstrated that 13-MTD could effectively inhibit in vitro and in vivo growth of various cancer cell lines by inducing apoptosis without significant toxic side effects, suggesting 13- MTD as a potential candidate for chemotherapy of human cancers. Expand
The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.
  • J. Li, Y. Ge, +6 authors K. Sun
  • Medicine, Chemistry
  • The Journal of clinical endocrinology and…
  • 16 March 2011
11β-HSD2 induction upon syncytialization is at least in part due to the increased expression of Sp1 upon activation of the cAMP pathway rather than the differential methylation of the HSD11B2 promoter. Expand
Identification of calcium-dependent phospholipase A2 isoforms in human and rat pancreatic islets and insulin secreting beta-cell lines.
Demonstration of the presence of type II and cytosolic PLA2 isoforms in islets provides the framework for further investigation of the regulation of PLA2isoforms and their role in insulin secretion. Expand
Thrombin increases expression of urokinase receptor by activation of the thrombin receptor.
Thrombin increases u-PAR expression by RPE cells by a mechanism involving activation of the seven transmembrane thrombin receptor. Expand
Biologically Active Recombinant Human Progastrin6–80Contains a Tightly Bound Calcium Ion*
It is concluded that recombinant human progastrin6–80 is biologically active and contains a single calcium ion, the first report of selective, high affinity binding of metal ions to a prohormone. Expand
Transcriptional Anti-repression
The results suggest that T3Rβ-2 regulates transcription through a novel anti-repression mechanism, recruiting SMRT, but preventing the subsequent formation of a functional corepressor complex. Expand
Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts.
Proper glucocorticoid exposure in utero is vital for normal fetal organ maturation, but excess glucocorticoids are detrimental to fetal growth and can even predispose the individuals to the high riskExpand