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  • Influence
Huntingtin Functions as a Scaffold for Selective Macroautophagy
It is demonstrated that Huntingtin, the Huntington disease gene product, functions as a scaffold protein for selective macroautophagy but it is dispensable for non-selective macroautogagy. Expand
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
The results show that Axin acts as a tumor suppressor by facilitating p53 function through integration of multiple factors. Expand
ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury.
Results indicate the ERK1/2 and p38 MAPK signaling pathway, especially the latter, play an important role in NO-mediated degeneration of neuron in the spinal cord following SCI. Expand
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
  • Z. Xu, R. Page, +5 authors S. Misra
  • Biology, Medicine
  • Nature Structural &Molecular Biology
  • 1 December 2008
It is shown that, rather than being a member of the Bag domain family, Bag2 contains a new type of Hsp70 NEF domain, which is called the 'brand new bag' (BNB) domain, indicating a distinct mechanism for the regulation of Hsc70-mediated protein folding by Bag2. Expand
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
The CHIP:UbcH5a structure emphasizes the importance of specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes. Expand
Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion
It is demonstrated that the newly formed microglia are actually solely derived from residualmicroglia, suggesting the absence of microglial progenitor cells in the adult brain. Expand
The removal of chromium (VI) and lead (II) from groundwater using sepiolite-supported nanoscale zero-valent iron (S-NZVI).
Supporting NZVI on sepiolite had the potential to become a promising technique for in situ heavy metal-contaminated groundwater remediation and both Langmuir isotherm model and Freundlich isotherms model were proposed. Expand
Human infection with avian influenza A H7N9 virus: an assessment of clinical severity
The clinical severity of human infections with avian influenza A H7N9 virus, which emerged in China in early 2013, seems to be less serious than has been previously reported. Expand
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
It is demonstrated that Sertoli cells derived from mesoderm can be directly converted into a multipotent state that possesses neural stem/progenitor cell properties and is capable of self-renewal and differentiating into glia and electrophysiologically functional neurons. Expand
SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling*
It is demonstrated that sumoylation plays a role for Axin to function in the JNK pathway and that dominant negative Axin mutants blocked PIAS-mediated JNK activation, in accordance with the requirement of sumoylator. Expand