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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain‐interacting protein kinase‐2 (HIPK2), which is linked toExpand
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Huntingtin Functions as a Scaffold for Selective Macroautophagy
Selective macroautophagy is an important protective mechanism against diverse cellular stresses. In contrast to the well-characterized starvation-induced autophagy, the regulation of selectiveExpand
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Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes
BackgroundUbiquitin (E3) ligases interact with specific ubiquitin conjugating (E2) enzymes to ubiquitinate particular substrate proteins. As the combination of E2 and E3 dictates the type andExpand
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Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
  • Z. Xu, R. Page, +5 authors S. Misra
  • Medicine, Biology
  • Nature Structural &Molecular Biology
  • 1 December 2008
Cochaperones are essential for Hsp70- and Hsc70-mediated folding of proteins and include nucleotide-exchange factors (NEFs) that assist protein folding by accelerating ADP-ATP exchange on Hsp70. TheExpand
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The removal of chromium (VI) and lead (II) from groundwater using sepiolite-supported nanoscale zero-valent iron (S-NZVI).
In this study, the synthesis and characterization of sepiolite-supported nanoscale zero-valent iron particles (S-NZVI) was investigated for the adsorption/reduction of Cr(VI) and Pb(II) ions.Expand
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Teleost skin, an ancient mucosal surface that elicits gut-like immune responses
  • Z. Xu, D. Parra, +7 authors J. Sunyer
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 24 July 2013
Skin homeostasis is critical to preserve animal integrity. Although the skin of most vertebrates is known to contain a skin-associated lymphoid tissue (SALT), very little is known about skin B-cellExpand
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ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury.
The enhanced production of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of neuronal apoptosis after acute traumatic spinal cord injury (SCI).Expand
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Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion
Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived fromExpand
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SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling*
Axin is a multifunctional protein, regulating Wnt signaling and the c-Jun N-terminal/stress-activated protein kinase (JNK/SAPK) pathway as well as tumorigenesis. In the present study, we found thatExpand
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Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility toExpand
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