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Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus
TLDR
It is found that Zbtb20 expression was initially activated in the hippocampal anlage at the onset of corticogenesis, and persisted in immature hippocampal neurons, and the field identities of the mutant CA3 and dentate gyrus were largely maintained, but their projections were severely impaired. Expand
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.
TLDR
It is shown that deregulation of microRNA122, a liver-specific microRNA, is a cause of both AFP elevation and a more biologically aggressive phenotype in HCC patients, and that serum AFP levels in H CC patients may be a surrogate marker for deregulated intracellular micro RNA122 signalling pathways in Hcc tissues. Expand
Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver
TLDR
The data point to ZBTB20 as a key regulator governing AFP gene transcription and postulate a new model for the postnatal gene repression of AFP in liver. Expand
Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.
TLDR
The data suggest that Lptn-DC are more potent adjuvants for peptide delivery to induce protective and therapeutic antitumor immunity. Expand
Zinc Finger Protein Zbtb20 Is Essential for Postnatal Survival and Glucose Homeostasis
TLDR
The data indicate that the phenotype of Zbtb20 knockout mice results from liver-dependent and -independent defects, suggesting that Zbt b20 plays nonredundant roles in multiple organ systems. Expand
Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin.
TLDR
The aim is to improve the therapeutic efficacy of DC-based tumor RNA vaccines by augmenting the preferential chemotaxis of DCs to T cells with a new approach to immunological intervention by chemokines. Expand
Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function
TLDR
This study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL 1 as a therapeutic target in the treatment of type 2 diabetes. Expand
Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9
TLDR
It is shown that the zinc finger protein Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes by repressing Sox9, a direct suppressor of Vegfa expression, which was ectopically upregulated at both mRNA and protein levels in the late ZbtB20-deficient hypertrophic zone. Expand
ZBTB20 is a sequence-specific transcriptional repressor of alpha-fetoprotein gene
TLDR
A cognate ZBTB20 site in AFP promoter is defined which mediates the postnatal repression of AFP gene in the liver, and was dispensable for AFP silencing in other tissues outside liver. Expand
Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
TLDR
This Article contains errors in the numbering of several papers in the reference list; reference 34 is incorrectly listed as reference 44 and references 35 to 44 are incorrectly list as 34 to 43. Expand
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