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Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity
Chronic pain caused by insults to the CNS (central neuropathic pain) is widely assumed to be maintained exclusively by central mechanisms. However, chronic hyperexcitablility occurs in primaryExpand
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Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A
TRPV4 (Transient Receptor Potential Vanilloid 4) channels are activated by a wide range of stimuli, including hypotonic stress, non-noxious heat and mechanical stress and some small molecule agonistsExpand
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TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury
Summary SCI increases TRPV1 in DRG neurons and enhances sensitivity of nociceptors to capsaicin. TRPV1 maintains behavioral hypersensitivity after SCI and promotes spontaneous activity inExpand
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Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function
Cochlear hair cells convert sound-induced vibration into electrical signals. FAM65B mutations cause hearing loss by an unknown mechanism. Using biochemistry and stochastic optical reconstructionExpand
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Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase
Little is known about intracellular signaling mechanisms that persistently excite neurons in pain pathways. Persistent spontaneous activity (SA) generated in the cell bodies of primary nociceptorsExpand
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Molecular Identity of the Mechanotransduction Channel in Hair Cells: Not Quiet There Yet
  • Z. Wu, U. Mueller
  • Medicine, Biology
  • The Journal of Neuroscience
  • 26 October 2016
Hair cells in the mammalian cochlea are specialized mechanosensory cells that convert sound-induced vibrations into electrochemical signals. The molecular composition of the mechanotransductionExpand
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TRPV1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity in Nociceptors After Spinal Cord Injury
iv Table of contents vi List of illustrations xi List of abbreviations xiv Chapter 1 --Introduction 1.1. Spinal cord injury induces chronic pain 1 1.2. Neurobiology of neuropathic pain 2 1.3.Expand
(284) Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with altered adenylyl cyclase
s The Journal of Pain S47 haplotype from block 2 was associated with a 5.94 decrease in CPI (p=0.001). Data from this study strongly implicated significant influences of ADRB2 polymorphisms andExpand