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Efficacy of Cyclophosphamide treatment for immunoglobulin G4-related disease with addition of glucocorticoids
Aim to evaluate the efficacy and safety of glucocorticoid monotherapy vs combination therapy of cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD). 102 newly diagnosed IgG4-RD patients were… Expand
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells.
Retinoic acid (RA) is a small molecular derivative of vitamin A that is stored in quiescent stellate cells in pancreas stroma. Cancer associated fibroblasts (CAFs) are activated fibroblast cells in… Expand
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration
5-lipoxygenase (5-LOX), a member of the lipoxygenase gene family, is a key enzyme assisting in the conversion of arachidonic acid to 5-HETE and leukotrienes. Tumor-associated macrophages (TAMs) have… Expand
Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects.
- Sheng-jie Nie, Tang Wen-ru, +6 authors Xiao Chun-jie
- Biology, Medicine
- Clinical biochemistry
- 1 February 2010
OBJECTIVES Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the… Expand
Fibroblast activation protein α-positive pancreatic stellate cells promote the migration and invasion of pancreatic cancer by CXCL1-mediated Akt phosphorylation.
- Z. Wen, Qiaofei Liu, +7 authors Q. Liao
- Chemistry, Medicine
- Annals of translational medicine
- 1 October 2019
Background Pancreatic stellate cells (PSCs) is a highly heterogeneic stroma cell population in pancreatic cancer tissue. Interaction between PSCs and pancreatic cancer cells has not been well… Expand
High Expression of Interleukin-22 and Its Receptor Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma
AbstractBackground The cytokine interleukin-22 (IL-22) and its receptor are present in the tumor microenvironment. Their function in pancreatic ductal adenocarcinoma (PDAC) remains largely unknown.… Expand
Vitamin D status and the risk of pancreatic cancer: a meta‐analysis
- Shanglong Liu, Y. Zhao, M. Dai, L. You, Z. Wen, J. Xu
- Chinese medical journal
- 5 September 2013
Background Vitamin D status in relation to pancreatic cancer risks is still inconsistent. This study was performed to evaluate the association between vitamin D status and risk of pancreatic cancer… Expand
Rhabdomyolysis presenting with severe hypokalemia in hypertensive patients: a case series
BackgroundRhabdomyolysis presenting with severe hypokalemia as the first manifestation of primary hyperaldosteronism is extremely rare.Case presentationTwo middle-aged Chinese females were admitted… Expand
Predictive role of single nucleotide polymorphisms of MTHFR and ABCG2 genes in the response to first-line chemotherapy in advanced colorectal cancer
Objective: To investigate the predictive role of single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) and breast cancer resistance protein (BCRP/ABCG2) in the… Expand