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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations.Expand
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SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data
We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled or individual next-generation sequencing (NGS) data. We formulate variant calling as a hypothesisExpand
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Analysis of shared heritability in common disorders of the brain
Brainstorming diseases Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multipleExpand
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GAME: detecting cis-regulatory elements using a genetic algorithm
TLDR
We introduce software, GAME, which utilizes a genetic algorithm to find optimal motifs in DNA sequences from a population of randomly generated starting motifs. Expand
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Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing
BackgroundTo facilitate the clinical implementation of genomic medicine by next-generation sequencing, it will be critically important to obtain accurate and consistent variant calls on personalExpand
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From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes
Genome-wide association studies (GWAS) have been fruitful in identifying disease susceptibility loci for common and complex diseases. A remaining question is whether we can quantify individualExpand
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A Markov random field model for network-based analysis of genomic data
TLDR
MOTIVATION A central problem in genomic research is the identification of genes and pathways involved in diseases and other biological processes. Expand
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Bioremediation of Oil Spills in Cold Environments: A Review
Oil spills have become a serious problem in cold environments with the ever-increasing resource exploitation, transportation, storage, and accidental leakage of oil. Several techniques, includingExpand
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Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy
Significance Spinal muscular atrophy (SMA), a common genetic motor neuron (MN) degenerative disease and leading hereditary cause of infant mortality, results from survival of motor neuron (SMN)Expand
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Twitter sentiment classification for measuring public health concerns
TLDR
An important task of public health officials is to keep track of health issues, such as spreading epidemics. Expand
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