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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor
DFU (5,5‐dimethyl‐3‐(3‐fluorophenyl)‐4‐(4‐methylsulphonyl)phenyl‐2(5H)‐furanone) was identified as a novel orally active and highly selective cyclo‐oxygenase‐2 (COX‐2) inhibitor. In CHO cells stablyExpand
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Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous family of myeloid cells that suppress T cell immunity in tumor-bearing hosts. In patients with colon cancer, MDSCs have recently beenExpand
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5‐lipoxygenase‐activating protein is an arachidonate binding protein
5‐Lipoxygenase‐activating protein (FLAP) is an 18‐kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However,Expand
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Early diagnosis of ataxia-telangiectasia using radiosensitivity testing.
OBJECTIVES To utilize radiosensitivity testing to improve early diagnosis of patients with ataxia-telangiectasia (A-T). STUDY DESIGN We established normal ranges for the colony survival assay (CSA)Expand
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Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement
Significance Cell division control protein 45 (Cdc45), a RecJ homologue, is essential in all eukaryotes. Cdc45 functions with the replisome CMG helicase where minichromosome maintenance (Mcm2–7)Expand
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Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer
  • Wei Tu, M. Luo, +6 authors Dean Tian
  • Biology, Medicine
  • Liver international : official journal of the…
  • 1 August 2012
Special AT‐rich binding protein‐1 (SATB1) reprograms chromatin organization and transcription profiles to promote tumour growth and metastasis.
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Treating Type 2 Diabetes Mellitus with Traditional Chinese and Indian Medicinal Herbs
Type II diabetes mellitus (T2DM) is a fast-growing epidemic affecting people globally. Furthermore, multiple complications and comorbidities are associated with T2DM. Lifestyle modifications alongExpand
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Automatic crystal centring procedure at the SSRF macromolecular crystallography beamline.
  • Z. Wang, Q. Pan, +6 authors J. He
  • Materials Science, Medicine
  • Journal of synchrotron radiation
  • 1 November 2016
X-ray diffraction is a common technique for determining crystal structures. The average time needed for the solution of a protein structure has been drastically reduced by a number of recentExpand
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Resveratrol differentially modulates inflammatory responses of microglia and astrocytes
  • X. Lu, Li-li Ma, +6 authors Y. Le
  • Biology, Medicine
  • Journal of Neuroinflammation
  • 17 August 2010
BackgroundInflammatory responses in the CNS mediated by activated glial cells play an important role in host-defense but are also involved in the development of neurodegenerative diseases.Expand
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Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map
To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM), we used microarrays, bioinformatics and the “Connectivity Map” (CMAP) to examineExpand
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