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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in theExpand
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Roles of K+ channels in regulating tumour cell proliferation and apoptosis
  • Z. Wang
  • Chemistry, Medicine
  • Pflügers Archiv
  • 27 March 2004
K+ channels are a most diverse class of ion channels in the cytoplasmic membrane and are distributed widely in a variety of cells including cancer cells. Cell proliferation and apoptosis (programmedExpand
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MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation
Background— A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca2+ current and shortening of theExpand
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Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties
Classical concepts of atrial fibrillation (AF) have been rooted in Moe’s multiple-wavelet hypothesis and simple cellular-automaton computer model. Recent experimental work has raised questions aboutExpand
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HERG K+ channel, a regulator of tumor cell apoptosis and proliferation.
The human ether-a-go-go related gene (HERG) encodes K+ channel identified as a molecular target for mutations underlying some forms of the long Q-T syndrome, a lethal cardiac arrhythmia. RecentExpand
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Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents.
BACKGROUND Kir2 subunits are believed to underlie the cardiac inwardly rectifying current I(K1). The subunit composition of native I(K1) currents is uncertain, and it has been suggested thatExpand
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Impairment of HERG K+ Channel Function by Tumor Necrosis Factor-α
Congestive heart failure (CHF) is associated with susceptibility to lethal arrhythmias and typically increases levels of tumor necrosis factor-α (TNF-α) and its receptor, TNFR1. CHF down-regulatesExpand
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MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Inward-rectifier K+ current (IK1) is believed to be an important regulator of reentrant-spiralExpand
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Functional M3 muscarinic acetylcholine receptors in mammalian hearts
In contrast to most peripheral tissues where multiple subtypes of muscarinic acetylcholine receptor (mAChR) coexist, with each of them playing its part in the orchestra of parasympatheticExpand
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