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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the… Expand
Roles of K+ channels in regulating tumour cell proliferation and apoptosis
- Z. Wang
- Chemistry, Medicine
- Pflügers Archiv
- 27 March 2004
K+ channels are a most diverse class of ion channels in the cytoplasmic membrane and are distributed widely in a variety of cells including cancer cells. Cell proliferation and apoptosis (programmed… Expand
MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation
Background— A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca2+ current and shortening of the… Expand
Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties
- J. Kneller, Renqiang Zou, E. Vigmond, Z. Wang, L. Leon, S. Nattel
- Medicine, Biology
- Circulation research
- 17 May 2002
Classical concepts of atrial fibrillation (AF) have been rooted in Moe’s multiple-wavelet hypothesis and simple cellular-automaton computer model. Recent experimental work has raised questions about… Expand
Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart.
HERG K+ channel, a regulator of tumor cell apoptosis and proliferation.
The human ether-a-go-go related gene (HERG) encodes K+ channel identified as a molecular target for mutations underlying some forms of the long Q-T syndrome, a lethal cardiac arrhythmia. Recent… Expand
Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents.
- G. Schram, M. Pourrier, Z. Wang, M. White, S. Nattel
- Medicine, Chemistry
- Cardiovascular research
- 1 August 2003
BACKGROUND Kir2 subunits are believed to underlie the cardiac inwardly rectifying current I(K1). The subunit composition of native I(K1) currents is uncertain, and it has been suggested that… Expand
Impairment of HERG K+ Channel Function by Tumor Necrosis Factor-α
- J. Wang, H. Wang, Y. Zhang, Huanhuan Gao, S. Nattel, Z. Wang
- Chemistry, Medicine
- Journal of Biological Chemistry
- 2 April 2004
Congestive heart failure (CHF) is associated with susceptibility to lethal arrhythmias and typically increases levels of tumor necrosis factor-α (TNF-α) and its receptor, TNFR1. CHF down-regulates… Expand
MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
- Xiaobin Luo, Zhenwei Pan, +20 authors S. Nattel
- The Journal of clinical investigation
- 1 May 2013
Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Inward-rectifier K+ current (IK1) is believed to be an important regulator of reentrant-spiral… Expand
Functional M3 muscarinic acetylcholine receptors in mammalian hearts
In contrast to most peripheral tissues where multiple subtypes of muscarinic acetylcholine receptor (mAChR) coexist, with each of them playing its part in the orchestra of parasympathetic… Expand