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N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
TLDR
NAGly is the most effective lipid recruiter of BV-2 microglia currently reported and its effects mimic those of Abn-CBD, and the hypothesis that GPR18 is the previously unidentified 'Abn- CBD' receptor is supported.
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
TLDR
Two types of endogenous cannabinoid-receptor agonists have been identified thus far and an example of a third, ether-type endocannabinoid, 2-arachidonyl glyceryl ether (noladin ether), isolated from porcine brain is reported.
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.
TLDR
The data suggest that guanine-nucleotide-binding-protein-coupled receptors can interact with each other at a molecular level and that the formation of receptor dimers involving the intermolecular exchange of N- and C-terminal receptor domains may underlie this phenomenon.
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.
TLDR
It is confirmed that the presence of a chiral center on the N-alkyl substituent may lead to enantiomers which differ in their levels of binding (compounds 54, 57 and 55, 56).
Opiate-induced Adenylyl Cyclase Superactivation Is Isozyme-specific*
TLDR
The results suggest that the phenomena of tolerance and withdrawal involve specific adenylyl cyclase isozymes, and it is demonstrated that the superactivation is isozyme-specific.
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Several derivatives of cannabinol and the 1,1-dimethylheptyl homolog (DMH) of cannabinol were prepared and assayed for binding to the brain and the peripheral cannabinoid receptors (CB1 and CB2), as
D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties*
TLDR
Coimmunoprecipitation experiments indicate that D2 and D3 receptors are capable of physical interaction and form complexes with these fragments and that these complexes bind [3H]nemonapride less efficiently or are not correctly targeted to the membrane.
Chronic Opioid Treatment Induces Adenylyl Cyclase V Superactivation
TLDR
It is shown that this phenomenon can be reproduced and studied in COS-7 cells cotransfected with adenylyl cyclase type V and μ-opioid receptor cDNAs, and that it is not affected by the Ras dominant negative mutant N17-Ras.
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
TLDR
It is shown that PEA potently enhances the anti-proliferative effects of AEA on human breast cancer cells (HBCCs), in part by inhibiting the expression of fatty acid amide hydrolase (FAAH), the major enzyme catalysing AEA degradation.
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