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- Publications
- Influence
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
- J. Song, F. Gallou, J. T. Reeves, Z. Tan, N. Yee, C. Senanayake
- Chemistry, Medicine
- The Journal of organic chemistry
- 4 January 2006
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of carbonyl compounds. Cyano transfer from TMSCN to aldehydes and ketones… Expand
Start selective and rigidify: The discovery path towards a next generation of EGFR tyrosine kinase inhibitors.
- H. Engelhardt, D. Boese, +34 authors D. McConnell
- Chemistry, Medicine
- Journal of medicinal chemistry
- 5 November 2019
The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase… Expand
Efficient Iron‐Catalyzed Kumada Cross‐Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings
- F. Buono, Y. Zhang, +7 authors C. Senanayake
- Chemistry
- 1 May 2016
An efficient continuous flow iron-catalyzed Kumada cross-coupling was developed for the coupling of 2-chloropyrazine and various aryl Grignard reagents in presence of low catalyst loadings (0.5… Expand
N-Heterocyclic Carbene-Catalyzed Silyl Enol Ether Formation.
- J. Song, Z. Tan, J. Reeves, Daniel R Fandrick, N. Yee, C. Senanayake
- Chemistry
- 29 July 2008
A General Synthesis of Substituted Formylpyrroles from Ketones and 4-Formyloxazole.
- J. Reeves, J. Song, Z. Tan, Heewon Lee, N. Yee, C. Senanayake
- Chemistry
- 18 September 2007
Organometallic methods for the synthesis and functionalization of azaindoles.
- J. Song, J. T. Reeves, F. Gallou, Z. Tan, N. Yee, C. Senanayake
- Chemistry, Medicine
- Chemical Society reviews
- 18 June 2007
Azaindoles (also called pyrrolopyridines) constitute essential subunits in many pharmaceutically important compounds. The synthesis of azaindoles has been a great synthetic challenge for chemists.… Expand
Copper catalyzed asymmetric propargylation of aldehydes.
- Daniel R Fandrick, K. Fandrick, +8 authors C. Senanayake
- Chemistry, Medicine
- Journal of the American Chemical Society
- 18 May 2010
The highly enantio- and regioselective copper catalyzed asymmetric propargylation of aldehydes with a propargyl borolane reagent is reported. The methodology demonstrated broad functional group… Expand
Room temperature palladium-catalyzed cross coupling of aryltrimethylammonium triflates with aryl Grignard reagents.
- J. T. Reeves, Daniel R Fandrick, +4 authors C. Senanayake
- Chemistry, Medicine
- Organic letters
- 2 September 2010
Aryltrimethylammonium triflates and tetrafluoroborates were found to be highly reactive electrophiles in the Pd-catalyzed cross coupling with aryl Grignard reagents. The coupling reactions proceed at… Expand
N-heterocyclic carbene catalyzed trifluoromethylation of carbonyl compounds.
- J. Song, Z. Tan, J. T. Reeves, F. Gallou, N. Yee, C. Senanayake
- Chemistry, Medicine
- Organic letters
- 5 May 2005
[reaction: see text]. A novel N-heterocyclic carbene (NHC) catalyzed trifluoromethylation reaction of carbonyl compounds was discovered. Both enolizable and nonenolizable aldehydes and alpha-keto… Expand
N-heterocyclic carbene-catalyzed Mukaiyama aldol reactions.
- J. Song, Z. Tan, J. T. Reeves, N. Yee, C. Senanayake
- Chemistry, Medicine
- Organic letters
- 13 February 2007
N-Heterocyclic carbenes were shown to be highly effective catalysts to promote Mukaiyama aldol reactions. In the presence of only 0.5 mol % of N-heterocyclic carbene (5), various aldehydes and… Expand