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Start selective and rigidify: The discovery path towards a next generation of EGFR tyrosine kinase inhibitors.
- H. Engelhardt, D. Böse, D. McConnell
- BiologyJournal of medicinal chemistry
- 5 November 2019
TLDR
Organometallic methods for the synthesis and functionalization of azaindoles.
- Jinhua J. Song, J. Reeves, F. Gallou, Zhulin Tan, N. Yee, C. Senanayake
- ChemistryChemical Society reviews
- 18 June 2007
TLDR
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
- Jinhua J. Song, F. Gallou, J. Reeves, Zhulin Tan, N. Yee, C. Senanayake
- ChemistryThe Journal of organic chemistry
- 4 January 2006
TLDR
Efficient Iron‐Catalyzed Kumada Cross‐Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings
- F. Buono, Yongda Zhang, C. Senanayake
- Chemistry, Engineering
- 1 May 2016
An efficient continuous flow iron-catalyzed Kumada cross-coupling was developed for the coupling of 2-chloropyrazine and various aryl Grignard reagents in presence of low catalyst loadings (0.5…
N-heterocyclic carbene-catalyzed silyl enol ether formation.
- Jinhua J. Song, Zhulin Tan, J. Reeves, Daniel R Fandrick, N. Yee, C. Senanayake
- ChemistryOrganic letters
- 31 January 2008
N-Heterocyclic carbenes (NHCs) were found to catalyze the silyl transfer from trialkylsilyl ketene acetals to ketones. In the presence of a catalytic amount of NHC 3 (IAd, 0.1 to 5 mol %), a series…
N-Heterocyclic Carbene-Catalyzed Silyl Enol Ether Formation.
- Jinhua J. Song, Z. Tan, J. T. Reeves, Daniel R Fandrick, N. Yee, C. Senanayake
- Chemistry
- 29 July 2008
Room temperature palladium-catalyzed cross coupling of aryltrimethylammonium triflates with aryl Grignard reagents.
- J. Reeves, Daniel R Fandrick, C. Senanayake
- ChemistryOrganic letters
- 2 September 2010
Aryltrimethylammonium triflates and tetrafluoroborates were found to be highly reactive electrophiles in the Pd-catalyzed cross coupling with aryl Grignard reagents. The coupling reactions proceed at…
Copper-catalyzed annulation of 2-formylazoles with o-aminoiodoarenes.
- J. Reeves, Daniel R Fandrick, C. Senanayake
- ChemistryThe Journal of organic chemistry
- 4 January 2010
In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also…
N-heterocyclic carbene catalyzed trifluoromethylation of carbonyl compounds.
- Jinhua J. Song, Zhulin Tan, J. Reeves, F. Gallou, N. Yee, C. Senanayake
- ChemistryOrganic letters
- 5 May 2005
TLDR
A Practical Procedure for Reduction of Primary, Secondary and Tertiary Amides to Amines
- J. Reeves, Zhulin Tan, C. Senanayake
- Chemistry
- 14 January 2013
A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and 1,1,3,3-tetramethyldisiloxane as reductant is described. The…
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