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Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
TLDR
The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins.
Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology.
TLDR
Examples of applications to small and large molecules, to in situ analysis, and to high-throughput analyses are presented and evidence is provided for both a heterogeneous charge-transfer mechanism and a droplet pick-up mechanism of ionization.
Ambient Mass Spectrometry
A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside
Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties
TLDR
This work has investigated the specific interaction of ABCB1 and ABCG2 with nilotinib, dasatinib and bosutinib, three clinically used, second‐generation inhibitors of the Bcr‐Abl tyrosine kinase activity.
Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure.
TLDR
Evidence is provided that the method is capable of generating fully desolvated protein ions at atmospheric pressure and allows the technique to be used for the study of ion-molecule reactions at atmospheric Pressure.
Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry.
Desorption electrospray ionization (DESI) mass spectrometry is used to detect trace amounts of explosives present on a variety of ambient surfaces in 5-second analysis times without any sample
Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry
TLDR
This first-in-human demonstration shows that the iKnife technology is ready for widespread use in the operating room to improve the accuracy of surgical intervention in cancer, and to demonstrate the translation to real-time use in vivo in a surgical environment.
Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient environment.
TLDR
Positive and negative ion DESI are used to characterize the active ingredients in pharmaceutical samples formulated as tablets, ointments, and liquids, and carryover effects are minimized in high-throughput on-line analysis of pharmaceutical samples.
Diagnostic Accuracy of Intraoperative Techniques for Margin Assessment in Breast Cancer Surgery: A Meta-analysis
TLDR
Pooled data suggest that frozen section and cytology have the greatest diagnostic accuracy, however, these methods are resource intensive and turnaround times for results have prevented widespread international adoption.
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project
TLDR
An unprecedented level of cooperation and collaboration has allowed the objective definition of cutoff target ranges for 114 markers to be applied to newborn screening of rare metabolic disorders.
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