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- Publications
- Influence
Membrane physical state controls the signaling mechanism of the heat shock response in Synechocystis PCC 6803: identification of hsp17 as a "fluidity gene".
- I. Horváth, A. Glatz, +8 authors L. Vigh
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 31 March 1998
The fluidity of Synechocystis membranes was adjusted in vivo by temperature acclimation, addition of fluidizer agent benzyl alcohol, or catalytic lipid hydrogenation specific to plasma membranes. The… Expand
Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
- Ĺ. Vígh, Péter N. Literáti, +11 authors B. Maresca
- Biology, Medicine
- Nature Medicine
- 1 October 1997
Preservation of the chemical architecture of a cell or of an organism under changing and perhaps stressful conditions is termed homeostasis. An integral feature of homeostasis is the rapid expression… Expand
Evidence for a lipochaperonin: association of active protein-folding GroESL oligomers with lipids can stabilize membranes under heat shock conditions.
- Z. Török, I. Horváth, +4 authors L. Vigh
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 18 March 1997
During heat shock, structural changes in proteins and membranes may lead to cell death. While GroE and other chaperone proteins are involved in the prevention of stress-induced protein aggregation… Expand
Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line
- E. Nagy, Zsolt Balogi, +11 authors L. Vigh
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 May 2007
Targeting of the Hsp function in tumor cells is currently being assessed as potential anticancer therapy. An improved understanding of the molecular signals that trigger or attenuate the stress… Expand
Membrane-Lipid Therapy in Operation: The HSP Co-Inducer BGP-15 Activates Stress Signal Transduction Pathways by Remodeling Plasma Membrane Rafts
- Imre Gombos, T. Crul, +17 authors I. Horváth
- Medicine, Biology
- PloS one
- 12 December 2011
Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches, causing dysregulated heat shock protein (HSP) expression. HSP co-inducer… Expand
Small heat-shock proteins regulate membrane lipid polymorphism
- N. Tsvetkova, I. Horváth, +8 authors L. Vigh
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 4 October 2002
Thermal stress in living cells produces multiple changes that ultimately affect membrane structure and function. We report that two members of the family of small heat-shock proteins (sHsp)… Expand
Loading red blood cells with trehalose: a step towards biostabilization.
- G. Satpathy, Z. Török, +6 authors N. Tsvetkova
- Biology, Medicine
- Cryobiology
- 1 October 2004
A method for freeze-drying red blood cells (RBCs) while maintaining a high degree of viability has important implications in blood transfusion and clinical medicine. The disaccharide trehalose, found… Expand
"Heat shock lipid" in cyanobacteria during heat/light-acclimation.
- Zsolt Balogi, Z. Török, +5 authors I. Horváth
- Biology, Medicine
- Archives of biochemistry and biophysics
- 15 April 2005
Parallel with the heat/light-induced thylakoid microdomain reorganization and thermal stabilization of photosynthesis we observed an increase in the level of the highly saturated… Expand
Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase
- Z. Török, N. Tsvetkova, +9 authors L. Vigh
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 3 March 2003
The hydroxylamine derivative bimoclomol (BM) has been shown to activate natural cytoprotective homeostatic responses by enhancing the capability of cells to cope with various pathophysiological… Expand
Contents of childbirth-related fear among couples wishing the partner's presence at delivery.
- P. Szeverényi, R. Póka, M. Hetey, Z. Török
- Medicine, Psychology
- Journal of psychosomatic obstetrics and…
- 1998
In order to explore the contents of childbirth-related fears, a survey was carried out among 216 pairs of prospective parents who opted for the presence of the partner at delivery. Each couple took… Expand