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The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer's disease in Chinese Hans
  • J. Shi, S. Zhang, +11 authors C. Ma
  • Biology, Medicine
  • American journal of medical genetics. Part B…
  • 2004
Beta‐site amyloid‐precursor protein cleaving enzyme (BACE1) is a candidate risk factor for Alzheimer's disease (AD) because of involving in generating β‐amyloid peptide, which is thought to play aExpand
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[The relationship between haplotypes of angiotensinogen gene and essential hypertension].
OBJECTIVE To investigate the relationship between the polymorphism of angiotensinogen gene (AGT) and the risk for hypertension in a Chinese population. METHODS Three polymorphisms of AGT gene wereExpand
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Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.
The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possibleExpand
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CETP Gene may be Associated with Advanced Age-Related Macular Degeneration in the Chinese Population
Abstract Objectives: This study aims to investigate whether variations in LIPC, CETP, ABCA1 and LPL, which are involved in high-density lipoprotein (HDL) metabolism, are associated with advancedExpand
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Genetic Variations in ADIPOQ Gene Are Associated with Chronic Obstructive Pulmonary Disease
Background Adiponectin is reported to be related to the development of chronic obstructive pulmonary disease (COPD). Genetic variants in the gene encoding adiponectin (ADIPOQ) have been reported toExpand
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Quantitative Trait Locus Analysis of Atherosclerosis in an Intercross Between C57BL/6 and C3H Mice Carrying the Mutant Apolipoprotein E Gene
Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) differ significantly in atherosclerosis susceptibility and plasma lipid levels on the apolipoprotein E-deficient (apoE−/−) background when fed aExpand
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Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia
We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercrossExpand
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Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease.
Coronary atherosclerotic heart disease (CAD) is a multifactorial disorder resulting from numerous gene-gene and gene-environment interactions. Lecithin:cholesterol acyltransferase (LCAT), a keyExpand
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Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene.
Bglu3 is a quantitative trait locus for fasting glucose on distal chromosome 1 identified in an intercross between C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E-deficient (apoE(-/-)) mice. ThisExpand
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Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer's disease in Chinese
Objective – To investigate into the relationship of apolipoprotein CI (ApoCI) polymorphism with sporadic Alzheimer's disease (AD) in Chinese.
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