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Sedation and antihistamines: a review of inter‐drug differences using proportional impairment ratios
TLDR
A complete evaluation of sedation should be performed through standardised objective and subjective tests, shown to be sensitive to the central effects of AHs. Expand
A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function.
TLDR
Fexofenadine at doses up to 180 mg appears free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment, as evidenced by the effects of the verum control promethazine 30 mg. Expand
An evaluation of the effects of high‐dose fexofenadine on the central nervous system: a double‐blind, placebo‐controlled study in healthy volunteers
TLDR
Two new types of antihistamines are reported that do not cross into the brain and therefore possess no intrinsic potential for impairing CNS function. Expand
A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg
TLDR
Fexofenadine 180 mg did not have disruptive effects on objective measures related to driving a car and aspects of psychomotor and cognitive function, even when combined with a dose of alcohol equivalent to 0.3 g/kg body weight, in a study in which the psychometric assessments were shown to be sensitive to impairment. Expand
Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side‐effects
TLDR
It is evident that only a very limited number of antihistamines can claim to be virtually free of both objective and subjective sedative effects, although the second generation ofAntihistamines are generally less impairing than the original ones; when prescribed at their recommended doses. Expand
The Acute and Sub-chronic Effects of Levocetirizine, Cetirizine, Loratadine, Promethazine and Placebo on Cognitive Function, Psychomotor Performance, and Weal and Flare
TLDR
In a study where the psychometric assessments were shown to be sensitive to impairment, l-CTZ 5 mg was found not only to be a potent inhibitor of the histamine-induced weal and flare reaction, but also to show evidence of potent peripheral inhibition of histamine. Expand
An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers
TLDR
The conclusion that cetirizine at its recommended therapeutic dose of 10 mg is demonstrably free from disruptive effects on aspects of psychomotor and cognitive function in a study where the psychometric assessments have been shown to be sensitive to impairment is demonstrated. Expand
The effects of cigarette smoking on overnight performance
TLDR
The data suggest that when performance is being measured overnight, smokers show little or no impairment, whilst the performance of non-smokers showed performance decrements. Expand
The Effects of Single and Repeated Administration of Ebastine on Cognition and Psychomotor Performance in Comparison to Triprolidine and Placebo in Healthy Volunteers
TLDR
Ebastine, at its recommended therapeutic doses of 10–20”mg, is demonstrably free from impairment on objective aspects of psychomotor and cognitive function in a study where the psychometric assessments were shown to be sensitive to disruptive effects, as evidenced by the action of the positive control, triprolidine 10 mg. Expand
Effects of three doses of 3‐indole pyruvic acid on subjective and objective measures of sleep and early morning performance
The effects of 3‐indole pyruvic acid (IPA) on sleep and morning after performance were investigated in 10 volunteers with previous complaints of mild insomnia. Three doses of IPA (100, 200 and 300Expand
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