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REVIEW: The alcohol‐preferring P rat and animal models of excessive alcohol drinking
TLDR
Findings indicate that the P rat can be effectively used in models assessing alcohol‐preference, a genetic predisposition for alcohol abuse and/or alcoholism, and excessive drinking using protocols of binge‐like or relapse‐like drinking. Expand
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons
TLDR
The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process. Expand
The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.
TLDR
Salsolinol produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors. Expand
Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats
TLDR
Findings indicate that alcohol drinking patterns differ across the age and sex of P rats, which suggests that the effectiveness of treatments for reducing excessive alcohol intake may vary depending upon the Age and/or sex of the subjects being tested. Expand
Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol‐preferring (P) rats
TLDR
The results indicated that chronic alcohol drinking enhanced extracellular glutamate concentrations in the mesolimbic system, as a result, in part, of reduced clearance, suggesting that enhanced glutamate neurotransmission may contribute to the maintenance of alcohol drinking. Expand
Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin
TLDR
The results of this study indicate that EtOH and ACD can independently produce reinforcing effects within the posterior VTA, and that activation of DA neurons mediates these effects. Expand
Effects of Repeated Alcohol Deprivations on Operant Ethanol Self-Administration by Alcohol-Preferring (P) Rats
TLDR
The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats. Expand
Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell.
TLDR
The findings from the current study indicate that local application of intermediate concentrations of ACD and SAL stimulated DA neurons in the pVTA, whereas higher concentrations may be having secondary effects within the p VTA that inhibit DA neuronal activity. Expand
Recent advances in animal models of alcohol craving and relapse
TLDR
Overall, the findings indicate substantial progress has been made in developing animal models of alcohol abuse, relapse and craving using these selectively bred rat lines, as well as outbred rats. Expand
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: Neurobiological and pharmacological validity
TLDR
Evidence is presented that rat animal models of alcoholism provide an ideal platform for developing and screening medications that target alcohol abuse and dependence in rodents, with particular emphasis on rats. Expand
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