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The choroid plexus-cerebrospinal fluid system: from development to aging.
The understanding of the mechanisms that underlie the dysfunction of the CP-CSF system in the elderly may help discover the treatments needed to reverse the negative effects of aging that lead to global CNS failure. Expand
The structure of the choroid plexus and the physiology of the choroid plexus epithelium.
The choroid plexuses appear to be source of CSF-borne hormones and growth factors, including insulin-like growth factor II (IGF II), vasopressin (VP) and transforming growth factor beta1 (TGF-beta1), and synthesise the thyroid transporting protein transthyretin and transferrin and can chelate heavy metals. Expand
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
  • Z. Redzic
  • Biology, Medicine
  • Fluids and Barriers of the CNS
  • 18 January 2011
A number of specific transport proteins are expressed in brain capillary endothelial cells and CP epithelial cells that provide transport of nutrients and ions into the CNS and removal of waste products and ions from the brain extracellular fluids. Expand
Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells
In both RBEC and RCPEC, adenosine uptake from the opposite chambers was Na+‐independent and partially inhibited by nitrobenzylthioinosine, indicating the presence of the equilibrative sensitive transporter rENT1. Expand
The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?
Whether or not suppression of microglial activity after CI is beneficial for neurological outcome still remains unclear and current evidence suggests that no simple answer could be given to this question. Expand
Brain to blood efflux transport of adenosine: blood–brain barrier studies in the rat
Kinetic parameters suggest that under conditions of elevated ISF adenosine in hypoxia/ischaemia, BBB efflux transport could increase up to 25% of the uptake into neurones/glia and become an important mechanism to oppose the rise in ISF concentration. Expand
Expression and functional activity of nucleoside transporters in human choroid plexus
BackgroundHuman equilibrative nucleoside transporters (hENTs) 1-3 and human concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus (hCP) play a role in the homeostasis ofExpand
The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus
The results suggest that the activity of xanthine oxidase in the brain of the sheep is very low so the metabolic degradation of purines is carried out only as far as hypoxanthine which then accumulates in the CSF. Expand
The kinetics of hypoxanthine transport across the perfused choroid plexus of the sheep
The results suggest that hypoxanthine uptake was Na+-independent, which means that transport system on the basolateral membrane can mediate the transport in both directions, and it seems that the transport of purine nucleobases through basol lateral membrane is mediated via a common transporter which is different from the nucleoside transporters. Expand
Uneven distribution of nucleoside transporters and intracellular enzymatic degradation prevent transport of intact [14C] adenosine across the sheep choroid plexus epithelium as a monolayer in primary
It appears that CPEC in primary cultures act as an enzymatic barrier towards adenosine, indicating that intracellular phosphorylation into nucleotides might be a reason for the low transcellular permeability. Expand