• Publications
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Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)
In a model of established arthritis, CP-690,550 rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue through a mechanism likely involving the inhibition of STAT1 signaling. Expand
Cell adhesion molecules, leukocyte trafficking, and strategies to reduce leukocyte infiltration.
By understanding the cellular and molecular events in leukocyte-endothelial cell interactions, therapeutic strategies are being developed in several animal models and diseases in domestic animal species to overcome tissue damage induced by excessive leukocytes infiltration. Expand
Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury.
Findings support a mechanism for increases in serum enzyme levels through M-CSF regulation of tissue macrophage homeostasis without concomitant histopathological changes in either the hepatic or skeletal system. Expand
Renal Pathophysiologic Role of Cortical Tubular Inclusion Bodies
Drug-induced renal inclusion bodies associated with the oral administration of a norepinephrine/serotonin reuptake inhibitor (NSRI) test article in Sprague-Dawley (SD) rats are rat-specific, do not represent an expression of nephrotoxicity, represent altered metabolism of d-amino acids, and are not relevant to human safety risk assessment. Expand
Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection.
During RSV or PI3 infection, COX-2 cellular expression is upregulated in airway bronchiolar and bronchial epithelial cells and macrophages, respiratory epithelium along with macrophage are important microanatomical compartments regulating the host inflammatory response during viral infection, and COx-2 may be a potential target for RSV and PI3 therapy. Expand
Characterization of Age- and Gender-related Changes in the Spleen and Thymus from Control Cynomolgus Macaques Used in Toxicity Studies
Several age- and gender-related changes in weights and ratios were noted in the thymus, which had a trend toward increased interlobular fat infiltration with increasing age in both males and females. Expand
Accuracy of ultrasound-guided fine-needle aspiration of the liver and cytologic findings in dogs and cats: 97 cases (1990-2000).
Acknowledging the limitations of cytology and the extent of discrepancies between cytologic and histopathologic findings in dogs and cats will help clinicians make better decisions in diagnosing liver disease. Expand
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.
Results suggest that the JAK inhibitor tofacitinib suppresses osteoclast-mediated structural damage to arthritic joints, and this effect is secondary to decreased RANKL production. Expand
Effects of cyclooxygenase inhibition on the gastrointestinal tract.
  • Z. Radi, N. Khan
  • Biology, Medicine
  • Experimental and toxicologic pathology : official…
  • 15 November 2006
COXIBs were developed to provide a selective COX-2 agent that at fully therapeutic doses demonstrated comparable therapeutic benefit to non-selective NSAIDs, without the attendantCOX-1-mediated GI toxicities. Expand
Pathophysiology of Cyclooxygenase Inhibition in Animal Models
  • Z. Radi
  • Biology, Medicine
  • Toxicologic pathology
  • 1 January 2009
COX-2 s-NSAIDs were developed to provide a selective COx-2 agent, while minimizing the attendant COX-1-mediated GI toxicities, and are shown to have both beneficial and detrimental effects on the skeletal system in animal models. Expand