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Pharmacokinetic/pharmacodynamic evaluation of inhalation drugs: application to targeted pulmonary delivery systems
Inhaled therapy with either glucocorticoids and/or β2-adrenergic drugs remains the mainstay of asthma treatment. In the last few years, a number of new products have been introduced into the marketExpand
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Advances in single-entity inhaled corticosteroid therapy.
The aim of inhaled corticosteroid (ICS) therapy is to achieve optimal drug targeting by producing pulmonary effects with a minimum of systemic side effects. To achieve a favorable safety and efficacyExpand
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Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate.
AIM Fluticasone propionate (FP) and mometasone furoate (MF) are inhaled corticosteroids that possess a high ratio of topical to systemic activity. The systemic bioavailability of MF has been claimedExpand
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Do intensive care patients need an individualized dosing regimen for levofloxacin?
OBJECTIVE In general, the pharmacokinetics (PK) of antibiotics in intensive care unit (ICU) patients are known to differ from healthy subjects. These differences can pose challenges in developingExpand
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