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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
  • Z. Li, J. Lu, +18 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 October 2008
MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with common translocations,Expand
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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
N6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However, its functions in normal and malignantExpand
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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
  • S. Mi, J. Lu, +13 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 11 December 2007
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, whereas acute myeloid leukemia (AML) is the most common acute leukemia in adults. In general, ALL has a better prognosis thanExpand
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Raf Kinase Inhibitory Protein Regulates Raf-1 but Not B-Raf Kinase Activation*
Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. Here, weExpand
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MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.
Human acute leukemias include acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It is estimated that 5,200 and 13,410 cases will be diagnosed with and 1,420 and 8,990 will die ofExpand
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Molecular Cloning and Characterization of a Mitogen-activated Protein Kinase-associated Intracellular Chloride Channel*
ERK7, a member of the mitogen-activated protein kinase family, has a carboxyl-terminal tail that is required for ERK7 activation, cellular localization, and its ability to inhibit DNA synthesis. ToExpand
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Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) are late complications of cytotoxic therapy used in the treatment of malignant diseases. The most common subtype ofExpand
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Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 andExpand
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Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia
One of the most serious consequences of cytotoxic cancer therapy is the development of therapy-related acute myeloid leukemia (t-AML), a neoplastic disorder arising from a multipotentialExpand
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Cloning and Characterization of MST4, a Novel Ste20-like Kinase*
MST4, a novel member of the germinal center kinase subfamily of human Ste20-like kinases, was cloned and characterized. Composed of a C-terminal regulatory domain and an N-terminal kinase domain,Expand
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