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Characterization of photoactivated singlet oxygen damage in single-molecule optical trap experiments.
Optical traps or "tweezers" use high-power, near-infrared laser beams to manipulate and apply forces to biological systems, ranging from individual molecules to cells. Although previous studies haveExpand
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Ion transport through dimethyl sulfoxide (DMSO) induced transient water pores in cell membranes
Abstract It is well known that dimethyl sulphoxide (DMSO) increases membrane permeability, which makes it widely used as a vehicle to facilitate drug delivery across biological membranes. However,Expand
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Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention.
BACKGROUND Aspirin and clopidogrel resistance plays a significant role in the development of cardiovascular ischemic events for ninety patients undergoing percutaneous coronary intervention. RecentExpand
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Activation of a mechanosensitive BK channel by membrane stress created with amphipaths
Some BK channels are activated in response to membrane stretch. However, it remains largely unknown which membrane component transmits forces to the channel and which part of the channel senses theExpand
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Cloning and Characterization of a Calcium-Activated Chloride Channel in Rat Uterus1
Abstract In a search for genes involved in regulation of uterine contractility, we cloned a novel calcium-activated chloride channel gene, named rat Clca4, from pregnant rat uterus. The gene sharesExpand
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Membrane Potential Dependent Duration of Action Potentials in Cultured Rat Hippocampal Neurons
Abstract(1) Fluctuations of the membrane potential states are essential for the brain functions from the response of individual neurons to the cognitive function of the brain. It has been reported inExpand
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Base triplet stepping by the Rad51/RecA family of recombinases
Matching DNA three bases at a time The exchange of genetic information between DNA strands is vital for accurate DNA repair and effective meiotic cell division. Using single-molecule methods andExpand
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The in vivo performance of polyvinyl alcohol macro-encapsulated islets.
Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages inExpand
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A mechanosensitive anion channel in Arabidopsis thaliana mesophyll cells.
Mechanosensitive ion channels are expected to play important roles in transducing mechanical stimuli into intracellular signals during the development and morphogenesis of higher plants. We haveExpand
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Effects of cholesterol levels on the excitability of rat hippocampal neurons
Changes in the cholesterol levels dynamically alter the microenvironment of the plasma membrane and have been shown to modify functions of ion channels. However, the cellular effect of theseExpand
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