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[20] Processing of X-ray diffraction data collected in oscillation mode.
The methods presented in the chapter have been applied to solve a large variety of problems, from inorganic molecules with 5 A unit cell to rotavirus of 700 A diameters crystallized in 700 × 1000 × 1400 A cell. Expand
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes.
A new approach that integrates data collection, data reduction, phasing and model building significantly accelerates the process of structure determination and on average minimizes the number of dataExpand
Multiparametric scaling of diffraction intensities.
The scaling model presented here includes: scale and temperature factor per batch of data; temperature factor as a continuous function of the radiation dose; absorption in the crystal; uneven exposure within a single diffraction image; and corrections for phenomena that depend on the diffraction peak position on the detector. Expand
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinctExpand
Structure and Control of the Actin Regulatory WAVE Complex
The structure shows that the activity-bearing VCA motif of WAVE is sequestered by a combination of intramolecular and intermolecular contacts within the WRC, and Rac and kinases appear to destabilize a WRC element that is necessary for VCA sequestration, suggesting the way in which these signals stimulate WRC activity towards the Arp2/3 complex. Expand
The crystal structure of the bacterial chaperonln GroEL at 2.8 Å
The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunitsExpand
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.
The crystal structure of the LSD1-CoREST complex forms an elongated structure with a long stalk connecting the catalytic domain of LSD1 and the CoREST SANT2 domain, suggesting its bivalent binding to nucleosomes, allowing efficient H3-K4 demethylation. Expand
WASH and WAVE actin regulators of the Wiskott–Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes
It is shown that WASH functions in cells within a 500 kDa core complex containing Strumpellin, FAM21, KIAA1033 (SWIP), and CCDC53, and biochemical and electron microscopic analyses show that the WASH and WAVE complexes are structurally similar. Expand
Secondary structure of Huntingtin amino-terminal region.
It is proposed that the pathogenic polyQ expansion in the Htt protein increases the length of the random coil, which promotes aggregation and facilitates abnormal interactions with other proteins in cells. Expand