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Network biology: understanding the cell's functional organization
A key aim of postgenomic biomedical research is to systematically catalogue all molecules and their interactions within a living cell. There is a clear need to understand how these molecules and theExpand
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Hierarchical Organization of Modularity in Metabolic Networks
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, butExpand
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Lethality and centrality in protein networks
Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view isExpand
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The large-scale organization of metabolic networks
In a cell or microorganism, the processes that generate mass, energy, information transfer and cell-fate specification are seamlessly integrated through a complex network of cellular constituents andExpand
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Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality. Bcl-2 is localized to intracellular sites of oxygen free radical generation including mitochondria,Expand
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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma1–3. Bcl-2 has the unique oncogenic role of extending cell survival by inhibiting a variety of apoptoticExpand
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Experimental determination and system level analysis of essential genes in Escherichia coli MG1655.
Defining the gene products that play an essential role in an organism's functional repertoire is vital to understanding the system level organization of living cells. We used a genetic footprintingExpand
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Functional and topological characterization of protein interaction networks.
The elucidation of the cell's large-scale organization is a primary challenge for post-genomic biology, and understanding the structure of protein interaction networks offers an important startingExpand
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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repressExpand
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Global organization of metabolic fluxes in the bacterium Escherichia coli
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalysed biochemical reactions, is the most investigated complex intracellular web ofExpand
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