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- Publications
- Influence
Sequence complexity of disordered protein
Intrinsic disorder refers to segments or to whole proteins that fail to self‐fold into fixed 3D structure, with such disorder sometimes existing in the native state. Here we report data on the… Expand
Intrinsically disordered protein.
- A. Dunker, J. D. Lawson, +17 authors Z. Obradovic
- Medicine
- Journal of molecular graphics & modelling
- 2001
Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the random coil. The five following examples suggest that native protein structure can correspond to any of… Expand
The importance of intrinsic disorder for protein phosphorylation.
- L. Iakoucheva, P. Radivojac, +4 authors A. Dunker
- Biology, Medicine
- Nucleic acids research
- 1 February 2004
Reversible protein phosphorylation provides a major regulatory mechanism in eukaryotic cells. Due to the high variability of amino acid residues flanking a relatively limited number of experimentally… Expand
Length-dependent prediction of protein intrinsic disorder
- K. Peng, P. Radivojac, S. Vucetic, A. Dunker, Z. Obradovic
- Medicine, Computer Science
- BMC Bioinformatics
- 17 April 2006
TLDR
DisProt: the Database of Disordered Proteins
- Megan Sickmeier, J. A. Hamilton, +9 authors A. Dunker
- Biology, Medicine
- Nucleic Acids Res.
- 1 December 2006
TLDR
Optimizing Long Intrinsic Disorder Predictors with Protein Evolutionary Information
- K. Peng, S. Vucetic, P. Radivojac, C. Brown, A. Dunker, Z. Obradovic
- Biology, Medicine
- J. Bioinform. Comput. Biol.
- 1 February 2005
TLDR
Intrinsic Disorder and Protein Function
- A. Dunker, C. Brown, J. D. Lawson, L. Iakoucheva, Z. Obradovic
- Chemistry
- 1 May 2002
Exploiting heterogeneous sequence properties improves prediction of protein disorder
- Z. Obradovic, K. Peng, S. Vucetic, P. Radivojac, A. Dunker
- Mathematics, Medicine
- Proteins
- 2005
During the past few years we have investigated methods to improve predictors of intrinsically disordered regions longer than 30 consecutive residues. Experimental evidence, however, showed that these… Expand
Intrinsic disorder in cell-signaling and cancer-associated proteins.
- L. Iakoucheva, C. Brown, J. D. Lawson, Z. Obradovic, A. Dunker
- Biology, Medicine
- Journal of molecular biology
- 25 October 2002
The number of intrinsically disordered proteins known to be involved in cell-signaling and regulation is growing rapidly. To test for a generalized involvement of intrinsic disorder in signaling and… Expand
Intrinsic protein disorder in complete genomes.
- A. Dunker, Z. Obradovic, P. Romero, E. Garner, C. Brown
- Biology, Medicine
- Genome informatics. Workshop on Genome…
- 2000
Intrinsic protein disorder refers to segments or to whole proteins that fail to fold completely on their own. Here we predicted disorder on protein sequences from 34 genomes, including 22 bacteria, 7… Expand