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Sequence complexity of disordered protein
Intrinsic disorder refers to segments or to whole proteins that fail to self‐fold into fixed 3D structure, with such disorder sometimes existing in the native state. Here we report data on theExpand
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Intrinsically disordered protein.
Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the random coil. The five following examples suggest that native protein structure can correspond to any ofExpand
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The importance of intrinsic disorder for protein phosphorylation.
Reversible protein phosphorylation provides a major regulatory mechanism in eukaryotic cells. Due to the high variability of amino acid residues flanking a relatively limited number of experimentallyExpand
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Length-dependent prediction of protein intrinsic disorder
TLDR
We proposed two new predictor models, VSL1-M1 and VSL2-M2, to address this length-dependency problem in prediction of intrinsic protein disorder. Expand
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DisProt: the Database of Disordered Proteins
TLDR
The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs) by collecting and organizing knowledge regarding the experimental characterization and the functional associations. Expand
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Optimizing Long Intrinsic Disorder Predictors with Protein Evolutionary Information
TLDR
Protein existing as an ensemble of structures, called intrinsically disordered, has been shown to be responsible for a wide variety of biological functions and to be common in nature. Expand
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Exploiting heterogeneous sequence properties improves prediction of protein disorder
During the past few years we have investigated methods to improve predictors of intrinsically disordered regions longer than 30 consecutive residues. Experimental evidence, however, showed that theseExpand
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Intrinsic disorder in cell-signaling and cancer-associated proteins.
The number of intrinsically disordered proteins known to be involved in cell-signaling and regulation is growing rapidly. To test for a generalized involvement of intrinsic disorder in signaling andExpand
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Intrinsic protein disorder in complete genomes.
Intrinsic protein disorder refers to segments or to whole proteins that fail to fold completely on their own. Here we predicted disorder on protein sequences from 34 genomes, including 22 bacteria, 7Expand
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