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Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain.
Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus
Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells
The exclusive extrasynaptic presence of the δ subunit-containing receptors, together with their kinetic properties, suggests that tonic inhibition could be mediated mainly by Extrasynaptic α6β2/3δ receptors, whereas phasic inhibition is attributable to the activation of synaptic receptors.
Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells.
It is demonstrated that a tonic GABA(A) receptor-mediated conductance can be recorded from dentate gyrus granule cells of adult rats in in vitro slice preparations, and distinct pharmacological tools to selectively modify tonic and phasic inhibitions are identified, allowing future studies to investigate their specific roles in neuronal function.
Increased number of synaptic GABAA receptors underlies potentiation at hippocampal inhibitory synapses
The postsynaptic insertion of new GABAA receptors and the corresponding increase in post Synaptic responses augmenting the efficacy of mammalian inhibitory synapses are established.
The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus
- R. Luján, Z. Nusser, J. Roberts, R. Shigemoto, P. Somogyi
- BiologyThe European journal of neuroscience
- 1 July 1996
It is proposed that glutamatergic synapses with an irregular edge develop in order to increase the circumference of synaptic junctions leading to an increase in the metabotropic to ionotropic glutamate receptor ratio at glutamate release sites.
Release probability of hippocampal glutamatergic terminals scales with the size of the active zone
It is demonstrated that the numbers of several active-zone proteins, including presynaptic calcium channels, as well as the number of docked vesicles and the release probability, scale linearly with the active- Zone area.
Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude
Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites
- Andrea Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser
- BiologyNature Neuroscience
- 1 November 2002
The results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms.