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  • Influence
Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala
TLDR
Results indicate that either food ingestion is interpreted as a “stressful” event by certain neural circuits involving the central amygdala or that the CRH- and BN-related peptidergic systems may serve a much broader role than previously envisioned. Expand
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
TLDR
Whether commercially available botanicals directly affect the primary brain enzymes responsible for gamma-aminobutyric acid (GABA) metabolism is determined and possible in vivo mode of action is discussed. Expand
Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties.
TLDR
The phytochemistry and biological activity of Scutellaria lateriflora L. laterifolia (American skullcap) which has been traditionally used as a sedative and to treat various nervous disorders such as anxiety was studied and compounds may play a role in anxiolytic activity. Expand
The effects of chronic mild stress on male Sprague–Dawley and Long Evans rats I. Biochemical and physiological analyses
TLDR
It is concluded that a history of chronic stress significantly blunts corticosterone levels in Long Evans but not Sprague-Dawley rats following exposure to an acute stressor. Expand
Ethnopharmacological investigation of plants used to treat susto, a folk illness.
TLDR
This finding supports the contention that susto may represent what in the Western culture is defined as fear or anxiety, and hence may share the same psychological, biological or neural underpinnings. Expand
Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models.
TLDR
The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity, suggesting these compounds do not have sedative effects in rodents. Expand
The Effects of Anxiolytics and Other Agents on Rat Grooming Behavior a
BN and other peptides increase grooming activity in rodents. This increase in grooming activity caused by BN can be reversed by numerous agents. The most direct of these are BN receptor antagonistsExpand
Ethnopharmacology of Q'eqchi' Maya antiepileptic and anxiolytic plants: effects on the GABAergic system.
TLDR
Clearly, Q'eqchi' traditional knowledge of antiepileptic and anxiolytic plants is associated with the use of pharmacologically active plants, and it is suggested that the mechanism of action for some traditionally used plants may be mediated through the GABAergic system. Expand
Effects of intranasal and peripheral oxytocin or gastrin-releasing peptide administration on social interaction and corticosterone levels in rats
TLDR
Evidence is provided that intranasal peptide delivery can induce behavioral alterations in rodents which is consistent with findings from human studies and the peptide-induced changes in social interaction were not linked to fluctuations in corticosterone levels. Expand
Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae)
TLDR
This study demonstrates that SCE can be used to generate a betulinic acid‐enriched extract with significant anxiolysis in vivo, and provides a scientific basis for the ethnobotanical use of this traditional medicine and a promising lead for a natural health product to treat anxiety. Expand
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