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Do early-life events permanently alter behavioral and hormonal responses to stressors?
TLDR
It is suggested that genetic factors may influence dam–pup interactive styles and may thus proactively influence the response to subsequent stressors among vulnerable animals, in contrast, in relatively hardy animals the early‐life manipulations may have less obvious effects. Expand
Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions.
TLDR
It was observed that the selective loss of DA neurons achieved by the intra-ventral tegmental area (VTA) injection of 6-OHDA increased the firing activity of a subset of locus coeruleus (LC) NE neurons, demonstrating a net inhibitory role of the NE input on VTA DA neurons. Expand
Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
TLDR
A role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression, given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features. Expand
Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease
TLDR
Protection against nigral neuron degeneration in PD may be sufficient to facilitate normalized locomotor activity without necessitating striatal reinnervation, according to the results of a mouse model of PD. Expand
Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress
TLDR
Evidence supports the view that EE attenuates responses to certain anxiety provoking situations, and that these effects persist over time, as well as exerts therapeutic and protective effects against impending threat, enduring effects of past stressor(s) and subsequent stressors. Expand
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAA Receptor Subunits in Frontal Cortical Brain Region
TLDR
Interestingly, a partial analysis of the GABAA receptor functional genome revealed high cross-correlations between subunit expression in cortical regions of nondepressed individuals, suggesting a high degree of coordinated gene regulation, but in suicide brains, this regulation was perturbed, independent of overall subunit abundance. Expand
Stress, coping, uplifts, and quality of life in subtypes of depression: a conceptual frame and emerging data.
TLDR
Quality of life represents a functional index of the behavioral and cognitive impact of depression, and may prove to be a useful assessment tool in evaluating treatment efficacy. Expand
Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects.
TLDR
The results suggest that early life events may contribute to anxiety and/or ingestive disorders such as anorexia nervosa, bulimia and obesity. Expand
The pathogenesis of clinical depression: Stressor- and cytokine-induced alterations of neuroplasticity
TLDR
Depressive illness may be considered a disorder of neuroplasticity as well as one of neurochemical imbalances, and cytokines may act as mediators of both aspects of this illness. Expand
Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders
TLDR
The view is taken that synergy between stressors and inflammatory factors may promote pathological outcomes through their actions on neuropeptides and several neurotransmitters. Expand
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