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Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations.
TLDR
The rate constants, k(r), are determined for scavenging .OH radicals by melatonin, 5-methoxytryptamine (5-MeO-T), 5-hydroxytryptamines (serotonin), 6-chloromelatonin (6-Cl-MLT, 6-hydroxymelatonin), and kynurenine (KN) in aqueous solutions. Expand
Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
TLDR
Results show that ICG is a very promising dye for photodynamic therapy of melanomas. Expand
Oxidation of biological electron donors and antioxidants by a reactive lactoperoxidase metabolite from nitrite (NO2-): an EPR and spin trapping study.
TLDR
It is proposed that in the LPO/H2O2/NO2-/biological electron donor systems the nitrite functions as a catalyst because of its preferential oxidation by LPO to a strongly oxidizing metabolite, most likely a nitrogen dioxide radical *NO2, which then reacts with the biological substrates more efficiently than does LPO/. Expand
Interaction of Singlet Molecular Oxygen with Melatonin and Related Indoles ¶
TLDR
The results indicate that all the indoles studied, including MLT, are quite efficient yet very similar 1O2 quenchers, which shows that the exceptional antioxidant ability proposed for MLT is unsubstantiated when merely chemical mechanism(s) are considered in vivo. Expand
Lactoperoxidase-catalyzed oxidation of the anticancer agent mitoxantrone by nitrogen dioxide (NO2.) radicals.
TLDR
In the presence of nitrite ions (NO2-), MXH2 undergoes oxidation by the mammalian enzyme lactoperoxidase (LPO) and hydrogen peroxide and that the process proceeds at a rate that is proportional to NO2- concentration. Expand
Lactoperoxidase-catalyzed oxidation of melanin by reactive nitrogen species derived from nitrite (NO2-): an EPR study.
TLDR
The results suggest that melanin could function as a natural scavenger of this highly reactive nitrogen species, and may be relevant to the physiological functions of the melanin pigments in vivo. Expand
NO-dependent phototoxicity of Roussin's black salt against cancer cells.
TLDR
RBS in dark was toxic to cells at concentrations above 1 microM, which prevents its application as a systemic anticancer agent in vivo, unless it is applied locally. Expand
Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
TLDR
The results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy. Expand
Interaction of Singlet Molecular Oxygen with Melatonin and Related Indoles¶
Abstract Singlet molecular oxygen (1O2) is one of the major agents responsible for (photo)oxidative damage in biological systems including human skin and eyes. It has been reported that the neuralExpand
Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation
TLDR
The data suggest that vitamin D3 may be an adjuvant that modifies proton beam efficiency during melanoma therapy, and that calcitriol and calcidiol exert pleiotropic effects on melanoma cells. Expand
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