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Influence of dendritic structure on firing pattern in model neocortical neurons
The data indicate that En-1 is required for delineating the ventral AER boundary and for restricting expression of signalling molecules, such as Fgf-8 and Bmp-2, to the distalmost ectoderm, a function reminiscent of engrailed's role in compartment border formation in D r o s ~ p h i l a ~~ ~ ~ . Expand
Reliability of spike timing in neocortical neurons.
Data suggest a low intrinsic noise level in spike generation, which could allow cortical neurons to accurately transform synaptic input into spike sequences, supporting a possible role for spike timing in the processing of cortical information by the neocortex. Expand
Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism
Markov kinetic models were used to synthesize a complete description of synaptic transmission, including opening of voltage-dependent channels in the presynaptic terminal, release ofExpand
Neural correlates, computation and behavioural impact of decision confidence
The firing rates of many single neurons in the orbitofrontal cortex match closely to the predictions of confidence models and cannot be readily explained by alternative mechanisms, such as learning stimulus–outcome associations. Expand
Estimating intracellular calcium concentrations and buffering without wavelength ratioing.
The proposed method for determining intracellular free calcium concentration from single-wavelength fluorescence signals does not require independent estimates of resting [Ca(2+)] but relies on the measurement of fluorescence close to indicator saturation during an experiment, which makes it well suited to [ Ca( 2+)] indicators for which saturation can be achieved under physiological conditions. Expand
Speed and accuracy of olfactory discrimination in the rat
Results show that, for the purpose of odor quality discrimination, a fully refined olfactory sensory representation can emerge within a single sensorimotor or theta cycle, suggesting that each sniff can be considered a snapshot of the Olfactory world. Expand
A model of spike initiation in neocortical pyramidal neurons
A biophysical model was constructed to reconcile observations that dendritic and somatic sodium channel densities compatible with electrophysiological measurements were combined with much higher densities in the axon initial segment then, regardless of the site of stimulation, spikes initiated at the initial segment and subsequently invaded the dendrites. Expand
An Efficient Method for Computing Synaptic Conductances Based on a Kinetic Model of Receptor Binding
This paper shows that reasonable biophysical assumptions about synaptic transmission allow the equations for a simple kinetic synapse model to be solved analytically, and yields a mechanism that preserves the advantages of kinetic models while being as fast to compute as a single tr-function. Expand
LTP mechanisms: from silence to four-lane traffic
Findings regarding basic properties of synaptic transmission appear to reconcile diverging views about the mechanisms behind long-term potentation in the CA1 region of the hippocampus. Expand
Demixed principal component analysis of neural population data
A new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components and exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards is demonstrated. Expand