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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
SUMMARY The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that target Wnt-mediated cellularExpand
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Ad Hoc Synchronization Considered Harmful
Many synchronizations in existing multi-threaded programs are implemented in an ad hoc way. The first part of this paper does a comprehensive characteristic study of ad hoc synchronizations inExpand
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HierarchicalTopics: Visually Exploring Large Text Collections Using Topic Hierarchies
Analyzing large textual collections has become increasingly challenging given the size of the data available and the rate that more data is being generated. Topic-based text summarization methodsExpand
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Significant increase of surface ozone at a rural site, north of eastern China
Abstract. Ozone pollution in eastern China has become one of the top environmental issues. Quantifying the temporal trend of surface ozone helps to assess the impacts of the anthropogenic precursorExpand
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Evolution of surface O3 and PM2.5 concentrations and their relationships with meteorological conditions over the last decade in Beijing
Abstract In this study, hourly and daily records since 2005 and correlation, regression and composite methods were used to analyze the long-term evolution of surface O3 and PM2.5 concentrations atExpand
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Accurate and efficient filtering for the Intel thread checker race detector
We develop filters that filter 90-100% of all memory references from the datarace detection algorithm, resulting in speedups of 2.2-5.3x. Expand
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Impact of the Loess Plateau on the atmospheric boundary layer structure and air quality in the North China Plain: a case study.
  • Xiao-Ming Hu, Z. Ma, +6 authors M. Xue
  • Environmental Science, Medicine
  • The Science of the total environment
  • 15 November 2014
The North China Plain (NCP), to the east of the Loess Plateau, experiences severe regional air pollution. During the daytime in the summer, the Loess Plateau acts as an elevated heat source. TheExpand
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Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
  • J. Lu, Z. Ma, +7 authors Chuo Chen
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 15 July 2009
Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response)Expand
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Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling
Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and mortality rates due to the lack of effective therapy. Nucleotide‐binding oligomerization domain‐like receptor familyExpand
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The development of highly potent inhibitors for porcupine.
Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity. We recentlyExpand
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