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Termination of autophagy and reformation of lysosomes regulated by mTOR
Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles are catabolized. During starvation, the protein TOR (target of rapamycin), a nutrient-responsive kinase,Expand
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The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility
The assumption that each enzyme expresses a single enzymatic activity in vivo is challenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson's diseaseExpand
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Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.
BACKGROUND & AIMS Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 promoter might contribute toExpand
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Identification of genomic alterations in oesophageal squamous cell cancer
Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, withExpand
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Autophagic programmed cell death by selective catalase degradation.
  • L. Yu, F. Wan, +5 authors M. Lenardo
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 28 March 2006
Autophagy plays a central role in regulating important cellular functions such as cell survival during starvation and control of infectious pathogens. Recently, it has been shown that autophagy canExpand
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Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae
Genomic and proteomic approaches can provide hypotheses concerning function for the large number of genes predicted from genome sequences. Because of the artificial nature of the assays, however, theExpand
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Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations
Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide and occurs at a relatively high frequency in China. To identify genetic susceptibility loci for ESCC, weExpand
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MicroRNA-10b Promotes Migration and Invasion through KLF4 in Human Esophageal Cancer Cell Lines*
  • Y. Tian, A. Luo, +4 authors Z. Liu
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 14 January 2010
Recently, microRNAs have emerged as regulators of cancer metastasis through acting on multiple signaling pathways involved in metastasis. In this study, we have analyzed the level of miR-10b and cellExpand
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RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction
Synaptic communication requires the controlled release of synaptic vesicles from presynaptic axon terminals. Release efficacy is regulated by the many proteins that comprise the presynaptic releaseExpand
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Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies.
PURPOSE To conduct a systematic review of prospective studies assessing the association of vitamin D intake or blood levels of 25-hydroxyvitamin D [25(OH)D] with the risk of colorectal cancer usingExpand
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