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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2
- Adedamola Olayanju, I. Copple, +15 authors B. Park
- Biology, Medicine
- Free radical biology & medicine
- 1 January 2015
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules have been reported, very few chemical… Expand
Effects of Ginkgo biloba on dementia: An overview of systematic reviews.
OBJECTIVE To assess the cumulative evidence on the efficacy and effectiveness of Ginkgo biloba extract (GbE) in the treatment of dementia. DESIGN Overview of systematic reviews. METHODS… Expand
GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
- Q. Yuan, B. Hu, H. Su, K. So, Z. Lin, W. Wu
- Journal of brachial plexus and peripheral nerve…
- 25 October 2009
Background The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods We have used immunohistochemistry to investigate the expression of GAP-43 in… Expand
Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice
Abstract Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in the treatment of dysenteric disorders (also known as ulcerative… Expand
Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress
- Sin Bond Leung, Huina Zhang, C. Lau, Y. Huang, Z. Lin
- Evidence-based complementary and alternative…
- 26 March 2013
Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases through increased oxidative stress. Salidroside is an active ingredient of the root of Rhodiola rosea with… Expand
Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice.
ETHNOPHARMACOLOGICAL RELEVANCE Pogostemon cablin (Blanco) Benth is a well-known medicinal herb commonly used in many Asian countries for inflammatory diseases. Pogostone (PO), a natural product… Expand
The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation
BackgroundIn a cytotoxicity screen in serum-free medium, Guttiferone F showed strong growth inhibitory effect against prostate cancer cells.MethodsProstate cancer cells LNCaP and PC3 were treated… Expand
Ethyl acetate fraction of the root of rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment
Psoriasis is a skin disease associated with hyperproliferation and aberrant differentiation of keratinocytes. Our previous studies have identified the root of Rubia cordifolia L. as a potent… Expand
Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial.
- E. Yiu, K. M. Chan, +6 authors R. Tsang
- Journal of voice : official journal of the Voice…
- 1 September 2016
OBJECTIVES To investigate the effectiveness of acupuncture in treating phonotraumatic vocal fold lesions. STUDY DESIGN/METHODS A total of 123 dysphonic individuals with benign vocal pathologies… Expand
Satellite glia activation in dorsal root ganglion contributes to mechanical allodynia after selective motor fiber injury in adult rats.
- Q. Yuan, Xiaodong Liu, +5 authors Z. Lin
- Biomedicine & pharmacotherapy = Biomedecine…
- 30 April 2020
Increasing evidence suggests that activation of satellite glia cells (SGCs) in sensory ganglia play important roles in the development of neuropathic pain. The present study aimed to investigate the… Expand